The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications

Jeramiah J. Smith, Melissa C. Keinath

Research output: Contribution to journalArticlepeer-review

121 Scopus citations


It is generally accepted that many genes present in vertebrate genomes owe their origin to two whole-genome duplications that occurred deep in the ancestry of the vertebrate lineage. However, details regarding the timing and outcome of these duplications are not well resolved. We present high-density meiotic and comparative genomic maps for the sea lamprey (Petromyzon marinus), a representative of an ancient lineage that diverged from all other vertebrates ∼550 million years ago. Linkage analyses yielded a total of 95 linkage groups, similar to the estimated number of germline chromosomes (1n ∼ 99), spanning a total of 5570.25 cM. Comparative mapping data yield strong support for the hypothesis that a single whole-genome duplication occurred in the basal vertebrate lineage, but do not strongly support a hypothetical second event. Rather, these comparative maps reveal several evolutionarily independent segmental duplications occurring over the last 600+ million years of chordate evolution. This refined history of vertebrate genome duplication should permit more precise investigations of vertebrate evolution.

Original languageEnglish
Pages (from-to)1081-1090
Number of pages10
JournalGenome Research
Issue number8
StatePublished - Aug 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Smith and Keinath.

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


Dive into the research topics of 'The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications'. Together they form a unique fingerprint.

Cite this