The significance of low titer serum cryptococcal antigen testing from 2017 to 2023 performed in a tertiary care center

Thein Myint; Jenna R. Wilson; Mahesh Bhatt; Mark E. Irwin; Julie A. Ribes

doi:10.1093/mmy/myae093

The significance of low titer serum cryptococcal antigen testing from 2017 to 2023 performed in a tertiary care center

Thein Myint, Jenna R. Wilson, Mahesh Bhatt, Mark E. Irwin, Julie A. Ribes

Research output: Contribution to journal › Article › peer-review

Abstract

Several false positive lo w serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients w ere false positives. If a new SCrA g LFA ≤1:10 is detected, it should be repeated, and additional workup should be pursued.

Original language	English
Article number	myae093
Journal	Medical Mycology
Volume	62
Issue number	9
DOIs	https://doi.org/10.1093/mmy/myae093
State	Published - Sep 1 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024 .

Keywords

false positive
lateral flow assay
low titer
serum cryptococcal antigen

ASJC Scopus subject areas

Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1093/mmy/myae093

Cite this

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abstract = "Several false positive lo w serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients w ere false positives. If a new SCrA g LFA ≤1:10 is detected, it should be repeated, and additional workup should be pursued.",

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AU - Myint, Thein

AU - Wilson, Jenna R.

AU - Bhatt, Mahesh

AU - Irwin, Mark E.

AU - Ribes, Julie A.

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AB - Several false positive lo w serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients w ere false positives. If a new SCrA g LFA ≤1:10 is detected, it should be repeated, and additional workup should be pursued.

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The significance of low titer serum cryptococcal antigen testing from 2017 to 2023 performed in a tertiary care center

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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