The most widely used animal model of attention-deficit/hyperactivity disorder (ADHD) is the spontaneously hypertensive rat (SHR/NCrl), which best represents the combined subtype (ADHD-C). Recent evidence has revealed that a progenitor strain, the Wistar Kyoto from Charles River Laboratories (WKY/NCrl), is useful as a model of the inattentive subtype (ADHD-PI) and the Wistar Kyoto from Harlan Laboratories (WKY/NHsd) and the Sprague Dawley (SD) have been suggested as controls. Dopamine (DA) dysfunction in the striatum (Str) and nucleus accumbens core (NAc) is thought to play a significant role in the pathophysiology of ADHD but data obtained with the SHR is equivocal. Using high-speed chronoamperometric recordings with carbon fiber microelectrodes, we found that the SHR/NCrl displayed decreased KCl-evoked DA release versus the WKY/NCrl model of ADHD-PI in the dorsal Str. The WKY/NCrl and the WKY/NHsd control did not differ from each other; however, the control SD released less DA than the WKY/NCrl model of ADHD-PI in the dorsal Str and less than the control WKY/NHsd in the intermediate Str. The SHR/NCrl had faster DA uptake in the ventral Str and NAc versus both control strains, while the WKY/NCrl model of ADHD-PI exhibited faster DA uptake in the NAc versus the SD control. These results suggest that increased surface expression of DA transporters may explain the more rapid uptake of DA in the Str and NAc of these rodent models of ADHD.
|Number of pages||8|
|State||Published - Dec 2012|
Bibliographical noteFunding Information:
The authors disclose that Greg A. Gerhardt is the owner of Quanteon Limited Liability Company (Nicholasville, KY). Quanteon developed the FAST system utilized for these studies. No financial support was provided on behalf of Quanteon. The authors, therefore, agree that none have financial support, compensation, and personal financial holdings that could be perceived as constituting a potential conflict of interest. All authors have full control of the primary data and thus agree to allow the journal to review data if requested.
- Attention-deficit/ hyperactivity disorder (ADHD)
- Dopamine uptake
- Spontaneously hypertensive rat
- Wistar Kyoto rat
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience