The structural biology of enzymes involved in natural product glycosylation

Shanteri Singh, George N. Phillips, Jon S. Thorson

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Covering: up to 2012 The glycosylation of microbial natural products often dramatically influences the biological and/or pharmacological activities of the parental metabolite. Over the past decade, crystal structures of several enzymes involved in the biosynthesis and attachment of novel sugars found appended to natural products have emerged. In many cases, these studies have paved the way to a better understanding of the corresponding enzyme mechanism of action and have served as a starting point for engineering variant enzymes to facilitate to production of differentially-glycosylated natural products. This review specifically summarizes the structural studies of bacterial enzymes involved in biosynthesis of novel sugar nucleotides.

Original languageEnglish
Pages (from-to)1201-1237
Number of pages37
JournalNatural Product Reports
Issue number10
StatePublished - Oct 2012

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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