The substrates of Plk1, beyond the functions in mitosis

X. Shawn Liu; Bing Song; Xiaoqi Liu

doi:10.1007/s13238-010-0131-x

The substrates of Plk1, beyond the functions in mitosis

X. Shawn Liu, Bing Song, Xiaoqi Liu

Research output: Contribution to journal › Review article › peer-review

43 Scopus citations

Abstract

Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.

Original language	English
Pages (from-to)	999-1010
Number of pages	12
Journal	Protein and Cell
Volume	1
Issue number	11
DOIs	https://doi.org/10.1007/s13238-010-0131-x
State	Published - Nov 2010

Keywords

Polo-like kinase 1
phosphorylation
substrates

ASJC Scopus subject areas

Biotechnology
Biochemistry
Drug Discovery
Cell Biology

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10.1007/s13238-010-0131-x

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title = "The substrates of Plk1, beyond the functions in mitosis",

abstract = "Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.",

keywords = "Polo-like kinase 1, phosphorylation, substrates",

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AU - Song, Bing

AU - Liu, Xiaoqi

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N2 - Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.

AB - Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. In this short review, we briefly summarized the well-established functions modulated by Plk1 during mitosis. Beyond mitosis, we focused mainly on the unexpected processes in which Plk1 emerges as a critical player, including microtubule dynamics, DNA replication, chromosome dynamics, p53 regulation, and recovery from the G2 DNA-damage checkpoint. Our discussion is mainly based on the critical substrates targeted by Plk1 during these cellular events and the functional significance associated with each phosphorylation event.

KW - Polo-like kinase 1

KW - phosphorylation

KW - substrates

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The substrates of Plk1, beyond the functions in mitosis

Abstract

Keywords

ASJC Scopus subject areas

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