The SunBEAm birth cohort: Protocol design

Corinne Keet; Scott H. Sicherer; Supinda Bunyavanich; Cynthia Visness; Patricia C. Fulkerson; Alkis Togias; Wendy Davidson; Susan Perry; Sanaz Hamrah; Agustin Calatroni; Katina Robinson; Lars Dunaway; Carla M. Davis; Sara Anvari; Susan M. Leong-Kee; Gurjit Khurana Hershey; Emily DeFranco; Ashley Devonshire; Haejin Kim; Christine Joseph; Brent Davidson; Noel K. Strong; Angela J. Tsuang; Marion Groetch; Julie Wang; Jennifer Dantzer; Kim Mudd; Abimbola Aina; Wayne Shreffler; Qian Yuan; Virginia Simmons; Donald Y.M. Leung; Jessica Hui-Beckman; Jania Arcia Ramos; Sharon Chinthrajah; Virginia Winn; Tina Sindher; Stacie M. Jones; Nirvana A. Manning; Amy M. Scurlock; Edwin Kim; Alison Stuebe; James E. Gern; Anne Marie Singh; Jennifer Krupp; Robert A. Wood

doi:10.1016/j.jacig.2023.100124

The SunBEAm birth cohort: Protocol design

Corinne Keet, Scott H. Sicherer, Supinda Bunyavanich, Cynthia Visness, Patricia C. Fulkerson, Alkis Togias, Wendy Davidson, Susan Perry, Sanaz Hamrah, Agustin Calatroni, Katina Robinson, Lars Dunaway, Carla M. Davis, Sara Anvari, Susan M. Leong-Kee, Gurjit Khurana Hershey, Emily DeFranco, Ashley Devonshire, Haejin Kim, Christine JosephBrent Davidson, Noel K. Strong, Angela J. Tsuang, Marion Groetch, Julie Wang, Jennifer Dantzer, Kim Mudd, Abimbola Aina, Wayne Shreffler, Qian Yuan, Virginia Simmons, Donald Y.M. Leung, Jessica Hui-Beckman, Jania Arcia Ramos, Sharon Chinthrajah, Virginia Winn, Tina Sindher, Stacie M. Jones, Nirvana A. Manning, Amy M. Scurlock, Edwin Kim, Alison Stuebe, James E. Gern, Anne Marie Singh, Jennifer Krupp, Robert A. Wood

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.

Original language	English
Article number	100124
Journal	Journal of Allergy and Clinical Immunology: Global
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/j.jacig.2023.100124
State	Published - Aug 2023

Bibliographical note

Publisher Copyright:
© 2023 The Author(s)

Funding

Funded by the following grants from NIAID/National Institutes of Health (NIH): UM2AI130836, UM1AI130838, UM1AI130839, UM1AI130781, UM1AI130936, UM1AI130936, UM1AI130780, UM1AI130934, UM1AI130570, UM1AI173380, UM1AI151958, and UM1AI109565. We acknowledge the following individuals who made this work possible: Acara Carter; Adam Glawe, MS; Ajay Eapen, MD; Alana Snowden, BS; Alexander Grishin, PhD; Alexis Gemelas, CRC; Alysar Bittar, RN; Amanda Cyrus, BA; Amanda Vega, BA; Amber Ali, BS; Amit Singh; Amy Caulum, RD; Amy Dresen, BS; Amy Eapen, MD; Ana P. Aguirre, BA; Andrea Gasparoto De Medeiros Amarante, RN, MS; Andrew Long, PharmD; Andrew Winslow, MD; Anna Anderson, MD; Anna-Liisa Vockell, MSN, BSN/RN; Asma Bazzy, RN; Berenice Alfaro, RN; Beth A. Mattucci, RN; Bin Su, PhD; Briahnna Austin, MS; Bruce J. Lanser, MD, MPH; Bryanna Oakley, BS; Bryle Barrameda, BA; Carissa Keung, BS; Caroline Bronchick, RN; Cassandra Thomas, RN; Catherine Feight; Cecilia Berin, PhD; Channon Campbell, RN; Chivon McMullen Jackson, RN, MS; Christen M. Hillenbrand, BS; Christine Johnson, PhD; Claire Hillier, BS; Daisy Tran Vita, RN, BSN; Daniel Jackson, MD; Danielle Whiteside, BA; Deanna Hamilton, RN; Deiny DeLaCerda, RN; Edward Zoratti, MD; Elika Eshghi, BS; Elizabeth Wash, RN, MSN, FNP-BC; Emily English, RN, MSN, CPNP; Emily Gallagher, BSN, MPH; Emily Seminara, BS; Eric Schauberger, DO, PhD; Erin Kane, BA; Estrella Guerrero, BS; Fabian Rivera, MBA; Fernanda Ochoa Toro; Galina Grishina, MS; Gerald Nepom, MD, PhD; Gina Crisafi, BS; Gledson Hanelt, RN; Harold Ames, MS; Holly Semble, BSN, RN; Inga Peter, PhD; Irina Burd, MD; Jane Rice, RN; Janelle Aby; Janine Westra; Jennifer Bagley, BSN; Jennifer Bump, MD, MBA; Jennifer Fishman, RN; Jennifer Martin, CCRP; Jennifer Smith, BS; Jenny Nguyen, BS; Jeri Wolven, RN; Jessica Macdougall, MD; Joanna Grabowska, MS; Jocelyn Chang, RD, MS; Jourdon Robinson, MS; Julia Santarosa, BA; Julie Seung; Jyothi Tirumalasetty, MD; Kaci Elrod, BS; Karen Dorman, RN, MS; Kari Nadeau, MD, PhD; Karla Ramirez, MD; Kathy Pitts, PNP, PhD; Katie Cruz; Katrina Bakhl, BA; Kimberly Kersey, CRC; Kjersti Aagaard, MD; Latha Satish, PhD; Latina Robinson, RD; Laura Susick, PhD; Lauren Herlihy, RN, MSN, CPNP; Lindsay Stewart; Lucia Costanza, BA; Mackenzie Keil, MS; Mae Yefimov; Makeda Pinnock, RN; Marco Ramirez-Gama, BS; Margaret E. Shannon, MA; Margaret Warren; Meg Hunter, BS; Melissa Hearrell, FNP, MSN; Melissa Yaeger, BS; Michael G. Sherenian, MD; Michael Marget, BA; Michele Cootauco, CRNP; Michelle Backer; Michelle Huffaker, MD; Michelle Mishoe, MS; Mikaela Hairston, RN; Mike Kulis, PhD; Mollie Schrodi, BSN; Molly Boone, RD; Morgan McGee; Nelly Hernandez, BS; Olisabueze E. Dimbo, BS; Olivia Raeber, PhD; Pamela Groh, RN/CRC; Patricia Taylor, NP; Peter K. Amezcua, CRC; Raul Giron, BS; Rebekah L. Epstein, BS; Rediet Bayou; Rida Saeed; Robert Rossi, MD; Rose Madison, BA; Safia Nawaz, MD; Samantha Henry, MS; Samuel J. Arbes, DDS, MPH, PhD; Sarah Bennick, RN, MSN, CPNP; Scott Boyd, MD, PhD; Shannon Garcia, BS; Shelley Randall; Sima Ramratnam, MD; Sky Strange, CRC; Stacey Bellemore, MS; Susan Leung, RN; Susan Raine, MD, JD; Suzanne Barshow, MD; Suzanne House, BS; Tiffany Narine, MSC; Timothy Sun; Valentina Vannoni, LLC; Veronica Chacko, BS; Warren Blackmon, BS; William Taylor, BA; Zeping Wang, CRC.

Funders	Funder number
CRNP
FNP-BC
Fernanda Ochoa Toro
National Institutes of Health (NIH)	UM1AI173380, UM1AI151958, UM1AI109565, UM1AI130570, UM1AI130839, UM1AI130838, UM2AI130836, UM1AI130781, UM1AI130780, UM1AI130934, UM1AI130936
National Institutes of Health (NIH)
National Institute of Allergy and Infectious Diseases

Keywords

Food allergy
atopic dermatitis
birth cohort
eczema
multiomics
omics
systems biology

ASJC Scopus subject areas

Immunology and Allergy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jacig.2023.100124

Cite this

Keet, C., Sicherer, S. H., Bunyavanich, S., Visness, C., Fulkerson, P. C., Togias, A., Davidson, W., Perry, S., Hamrah, S., Calatroni, A., Robinson, K., Dunaway, L., Davis, C. M., Anvari, S., Leong-Kee, S. M., Hershey, G. K., DeFranco, E., Devonshire, A., Kim, H., ... Wood, R. A. (2023). The SunBEAm birth cohort: Protocol design. Journal of Allergy and Clinical Immunology: Global, 2(3), Article 100124. https://doi.org/10.1016/j.jacig.2023.100124

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title = "The SunBEAm birth cohort: Protocol design",

abstract = "Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.",

keywords = "Food allergy, atopic dermatitis, birth cohort, eczema, multiomics, omics, systems biology",

author = "Corinne Keet and Sicherer, {Scott H.} and Supinda Bunyavanich and Cynthia Visness and Fulkerson, {Patricia C.} and Alkis Togias and Wendy Davidson and Susan Perry and Sanaz Hamrah and Agustin Calatroni and Katina Robinson and Lars Dunaway and Davis, {Carla M.} and Sara Anvari and Leong-Kee, {Susan M.} and Hershey, {Gurjit Khurana} and Emily DeFranco and Ashley Devonshire and Haejin Kim and Christine Joseph and Brent Davidson and Strong, {Noel K.} and Tsuang, {Angela J.} and Marion Groetch and Julie Wang and Jennifer Dantzer and Kim Mudd and Abimbola Aina and Wayne Shreffler and Qian Yuan and Virginia Simmons and Leung, {Donald Y.M.} and Jessica Hui-Beckman and Ramos, {Jania Arcia} and Sharon Chinthrajah and Virginia Winn and Tina Sindher and Jones, {Stacie M.} and Manning, {Nirvana A.} and Scurlock, {Amy M.} and Edwin Kim and Alison Stuebe and Gern, {James E.} and Singh, {Anne Marie} and Jennifer Krupp and Wood, {Robert A.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

month = aug,

doi = "10.1016/j.jacig.2023.100124",

language = "English",

volume = "2",

journal = "Journal of Allergy and Clinical Immunology: Global",

issn = "2772-8293",

publisher = "Elsevier BV",

number = "3",

}

Keet, C, Sicherer, SH, Bunyavanich, S, Visness, C, Fulkerson, PC, Togias, A, Davidson, W, Perry, S, Hamrah, S, Calatroni, A, Robinson, K, Dunaway, L, Davis, CM, Anvari, S, Leong-Kee, SM, Hershey, GK, DeFranco, E, Devonshire, A, Kim, H, Joseph, C, Davidson, B, Strong, NK, Tsuang, AJ, Groetch, M, Wang, J, Dantzer, J, Mudd, K, Aina, A, Shreffler, W, Yuan, Q, Simmons, V, Leung, DYM, Hui-Beckman, J, Ramos, JA, Chinthrajah, S, Winn, V, Sindher, T, Jones, SM, Manning, NA, Scurlock, AM, Kim, E, Stuebe, A, Gern, JE, Singh, AM, Krupp, J & Wood, RA 2023, 'The SunBEAm birth cohort: Protocol design', Journal of Allergy and Clinical Immunology: Global, vol. 2, no. 3, 100124. https://doi.org/10.1016/j.jacig.2023.100124

TY - JOUR

T1 - The SunBEAm birth cohort

T2 - Protocol design

AU - Keet, Corinne

AU - Sicherer, Scott H.

AU - Bunyavanich, Supinda

AU - Visness, Cynthia

AU - Fulkerson, Patricia C.

AU - Togias, Alkis

AU - Davidson, Wendy

AU - Perry, Susan

AU - Hamrah, Sanaz

AU - Calatroni, Agustin

AU - Robinson, Katina

AU - Dunaway, Lars

AU - Davis, Carla M.

AU - Anvari, Sara

AU - Leong-Kee, Susan M.

AU - Hershey, Gurjit Khurana

AU - DeFranco, Emily

AU - Devonshire, Ashley

AU - Kim, Haejin

AU - Joseph, Christine

AU - Davidson, Brent

AU - Strong, Noel K.

AU - Tsuang, Angela J.

AU - Groetch, Marion

AU - Wang, Julie

AU - Dantzer, Jennifer

AU - Mudd, Kim

AU - Aina, Abimbola

AU - Shreffler, Wayne

AU - Yuan, Qian

AU - Simmons, Virginia

AU - Leung, Donald Y.M.

AU - Hui-Beckman, Jessica

AU - Ramos, Jania Arcia

AU - Chinthrajah, Sharon

AU - Winn, Virginia

AU - Sindher, Tina

AU - Jones, Stacie M.

AU - Manning, Nirvana A.

AU - Scurlock, Amy M.

AU - Kim, Edwin

AU - Stuebe, Alison

AU - Gern, James E.

AU - Singh, Anne Marie

AU - Krupp, Jennifer

AU - Wood, Robert A.

PY - 2023/8

Y1 - 2023/8

N2 - Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.

AB - Background: Food allergy (FA) and atopic dermatitis (AD) are common conditions that often present in the first year of life. Identification of underlying mechanisms and environmental determinants of FA and AD is essential to develop and implement effective prevention and treatment strategies. Objectives: We sought to describe the design of the Systems Biology of Early Atopy (SunBEAm) birth cohort. Methods: Funded by the National Institute of Allergy and Infectious Diseases (NIAID) and administered through the Consortium for Food Allergy Research (CoFAR), SunBEAm is a US population-based, multicenter birth cohort that enrolls pregnant mothers, fathers, and their newborns and follows them to 3 years. Questionnaire and biosampling strategies were developed to apply a systems biology approach to identify environmental, immunologic, and multiomic determinants of AD, FA, and other allergic outcomes. Results: Enrollment is currently underway. On the basis of an estimated FA prevalence of 6%, the enrollment goal is 2500 infants. AD is defined on the basis of questionnaire and assessment, and FA is defined by an algorithm combining history and testing. Although any FA will be recorded, we focus on the diagnosis of egg, milk, and peanut at 5 months, adding wheat, soy, cashew, hazelnut, walnut, codfish, shrimp, and sesame starting at 12 months. Sampling includes blood, hair, stool, dust, water, tape strips, skin swabs, nasal secretions, nasal swabs, saliva, urine, functional aspects of the skin, and maternal breast milk and vaginal swabs. Conclusions: The SunBEAm birth cohort will provide a rich repository of data and specimens to interrogate mechanisms and determinants of early allergic outcomes, with an emphasis on FA, AD, and systems biology.

KW - Food allergy

KW - atopic dermatitis

KW - birth cohort

KW - eczema

KW - multiomics

KW - omics

KW - systems biology

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DO - 10.1016/j.jacig.2023.100124

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VL - 2

JO - Journal of Allergy and Clinical Immunology: Global

JF - Journal of Allergy and Clinical Immunology: Global

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ER -

The SunBEAm birth cohort: Protocol design

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this