TY - JOUR
T1 - The synthesis and structure-activity relationship of substituted N-phenyl anthranilic acid analogs as amyloid aggregation inhibitors
AU - Simons, Lloyd J.
AU - Caprathe, Bradley W.
AU - Callahan, Michael
AU - Graham, James M.
AU - Kimura, Takenori
AU - Lai, Yingjie
AU - LeVine, Harry
AU - Lipinski, William
AU - Sakkab, Annette T.
AU - Tasaki, Yoshikazu
AU - Walker, Lary C.
AU - Yasunaga, Tomoyuki
AU - Ye, Yuyang
AU - Zhuang, Nian
AU - Augelli-Szafran, Corinne E.
PY - 2009/2/1
Y1 - 2009/2/1
N2 - It is believed that β-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify β-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for β-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.
AB - It is believed that β-amyloid aggregation is an important event in the development of Alzheimer's disease. In the course of our studies to identify β-amyloid aggregation inhibitors, a series of N-phenyl anthranilic acid analogs were synthesized and studied for β-amyloid inhibition activity. The synthesis, structure-activity relationship, and in vivo activity of these analogs are discussed.
KW - Alzheimer's disease
KW - Amyloid aggregation
KW - Amyloid aggregation inhibitors
KW - Amyloid plaques
KW - Analogs
KW - Beta-amyloid
KW - Hsiao mouse model
KW - N-Phenyl anthranilic acid
KW - Tg2576 mice
UR - http://www.scopus.com/inward/record.url?scp=58549114656&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58549114656&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.12.049
DO - 10.1016/j.bmcl.2008.12.049
M3 - Article
C2 - 19121939
AN - SCOPUS:58549114656
SN - 0960-894X
VL - 19
SP - 654
EP - 657
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 3
ER -