The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults

Jean L. Fry; Brooke D. Munson; Katherine L. Thompson; Christopher S. Fry; Douglas Paddon-Jones; Emily J. Arentson-Lantz

doi:10.1038/s41598-022-10683-1

The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults

Jean L. Fry, Brooke D. Munson, Katherine L. Thompson, Christopher S. Fry, Douglas Paddon-Jones, Emily J. Arentson-Lantz

Research output: Contribution to journal › Article › peer-review

Abstract

Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.

Original language	English
Article number	6897
Journal	Scientific Reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-10683-1
State	Published - Dec 2022

Bibliographical note

Publisher Copyright:
© 2022, The Author(s).

Funding

Claude D. Pepper Older Americans Independence Center, University of Texas Medical Branch Grant number P30 AG024832. National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant number R01 AR071398-04S1.Nursing Research at the National Institutes of Health Grant number R01 NR012973. National Center for Research Resources Grant number 1UL1RR029876. National Center for Advancing Translational Sciences UL1TR000071. We sincerely thank Deborah Prusak and staff of the UTMB ITS-CRC and genomics core for their assistance.

Funders	Funder number
National Institutes of Health (NIH)	R01 NR012973
National Institutes of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases	R01 AR071398-04S1
National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Center for Advancing Translational Sciences (NCATS)	UL1TR000071
National Center for Advancing Translational Sciences (NCATS)
University of Texas Medical Branch

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General

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-10683-1

Cite this

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title = "The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults",

abstract = "Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.",

author = "Fry, {Jean L.} and Munson, {Brooke D.} and Thompson, {Katherine L.} and Fry, {Christopher S.} and Douglas Paddon-Jones and Arentson-Lantz, {Emily J.}",

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AU - Thompson, Katherine L.

AU - Fry, Christopher S.

AU - Paddon-Jones, Douglas

AU - Arentson-Lantz, Emily J.

PY - 2022/12

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AB - Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.

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The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

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