The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults

Jean L. Fry, Brooke D. Munson, Katherine L. Thompson, Christopher S. Fry, Douglas Paddon-Jones, Emily J. Arentson-Lantz

Research output: Contribution to journalArticlepeer-review


Inpatient populations are at increased risk of hyperglycemia due to factors such as medications, physical inactivity and underlying illness, which increases morbidity and mortality. Unfortunately, clinicians have limited tools available to prospectively identify those at greatest risk. We evaluated the ability of 10 common genetic variants associated with development of type 2 diabetes to predict impaired glucose metabolism. Our research model was a simulated inpatient hospital stay (7 day bed rest protocol, standardized diet, and physical inactivity) in a cohort of healthy older adults (n = 31, 65 ± 8 years) with baseline fasting blood glucose < 100 mg/dL. Participants completed a standard 75 g oral glucose tolerance test (OGTT) at baseline and post-bed rest. Bed rest increased 2-h OGTT blood glucose and insulin independent of genetic variant. In multiple regression modeling, the transcription factor 7-like 2 (TCF7L2) rs7903146 T allele predicted increases in 2-h OGTT blood glucose (p = 0.039). We showed that the TCF7L2 rs7903146 T allele confers risk for loss of glucose tolerance in nondiabetic older adults following 7 days of bed rest.

Original languageEnglish
Article number6897
JournalScientific Reports
Issue number1
StatePublished - Dec 2022

Bibliographical note

Funding Information:
Claude D. Pepper Older Americans Independence Center, University of Texas Medical Branch Grant number P30 AG024832. National Institute of Arthritis and Musculoskeletal and Skin Diseases Grant number R01 AR071398-04S1.Nursing Research at the National Institutes of Health Grant number R01 NR012973. National Center for Research Resources Grant number 1UL1RR029876. National Center for Advancing Translational Sciences UL1TR000071.

Funding Information:
We sincerely thank Deborah Prusak and staff of the UTMB ITS-CRC and genomics core for their assistance.

Publisher Copyright:
© 2022, The Author(s).

ASJC Scopus subject areas

  • General


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