TY - JOUR
T1 - The T-cell-specific adapter protein family
T2 - TSAd, ALX, and SH2D4A/SH2D4B
AU - Lapinski, Philip E.
AU - Oliver, Jennifer A.
AU - Bodie, Jennifer N.
AU - Marti, Francesc
AU - King, Philip D.
PY - 2009/11
Y1 - 2009/11
N2 - Summary: Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.
AB - Summary: Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed.
KW - Adapter proteins
KW - Autoimmunity
KW - Knockout mice
KW - Protein tyrosine kinases
KW - Signal transduction
KW - T lymphocytes
UR - https://www.scopus.com/pages/publications/70350413774
UR - https://www.scopus.com/inward/citedby.url?scp=70350413774&partnerID=8YFLogxK
U2 - 10.1111/j.1600-065X.2009.00829.x
DO - 10.1111/j.1600-065X.2009.00829.x
M3 - Review article
C2 - 19909368
AN - SCOPUS:70350413774
SN - 0105-2896
VL - 232
SP - 240
EP - 254
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -