The Toxoplasma gondii Parasitophorous Vacuole Membrane. A Multifunctional Organelle in the Infected Cell

Anthony P. Sinai

doi:10.1016/B978-0-12-396481-6.00011-8

The Toxoplasma gondii Parasitophorous Vacuole Membrane. A Multifunctional Organelle in the Infected Cell

Anthony P. Sinai

Microbiology, Immunology, and Molecular Genetics

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Scopus citations

Abstract

Toxoplasma gondii is an obligate intracellular parasite that lives within its host cells within a membrane-bound vacuole. The parasitophorous vacuole membrane is host-derived, yet extensively modified by the parasite to facilitate nutrient acquisition and avoid host defenses. Formation of the vacuole also is accompanied by extensive host cell cytoskeletal rearrangement and organellar recruitment to the vacuole. This chapter reviews recent experimental insights into the biology and composition of this critical and dynamic host-parasite interface.

Original language	English
Title of host publication	Toxoplasma Gondii
Subtitle of host publication	The Model Apicomplexan - Perspectives and Methods: Second Edition
Pages	375-387
Number of pages	13
DOIs	https://doi.org/10.1016/B978-0-12-396481-6.00011-8
State	Published - Sep 2013

Keywords

Cyst wall
Moving junction
Parasitophorous vacuole network
Phagosome

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-396481-6.00011-8

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AB - Toxoplasma gondii is an obligate intracellular parasite that lives within its host cells within a membrane-bound vacuole. The parasitophorous vacuole membrane is host-derived, yet extensively modified by the parasite to facilitate nutrient acquisition and avoid host defenses. Formation of the vacuole also is accompanied by extensive host cell cytoskeletal rearrangement and organellar recruitment to the vacuole. This chapter reviews recent experimental insights into the biology and composition of this critical and dynamic host-parasite interface.

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KW - Moving junction

KW - Parasitophorous vacuole network

KW - Phagosome

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BT - Toxoplasma Gondii

ER -

The Toxoplasma gondii Parasitophorous Vacuole Membrane. A Multifunctional Organelle in the Infected Cell

Abstract

Keywords

ASJC Scopus subject areas

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