The trend of amino-acid gain is consistent with a doublet code

Raphael Finkel, Heinz Kohler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The present-day genetic code, while universal, is not the result of a "frozen accident", but has evolved over time. Analysis of amino-acid frequency has recently identified amino acids that were recruited early and late into the genetic code. We use this observation to lend support to a hypothesis that the current quaternary triplet genetic code comes from an earlier quaternary doublet code, and before that from a binary singlet code.

Original languageEnglish
Pages (from-to)209-211
Number of pages3
JournalCurrent Proteomics
Issue number3
StatePublished - 2010


  • Aminoacids
  • Binary code
  • Code capture
  • Codons
  • Evolution
  • Genetic code
  • Triplet

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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