The Trend of Urinary N Terminal Probrain Natriuretic Peptide in Extremely Low Birth Weight Infants during the Neonatal Period

Safdar S. Khan; Henrietta S. Bada; Maritza Torres; Melvin Almodovar; Mina Hanna

doi:10.1055/a-1692-1039

The Trend of Urinary N Terminal Probrain Natriuretic Peptide in Extremely Low Birth Weight Infants during the Neonatal Period

Safdar S. Khan, Henrietta S. Bada, Maritza Torres, Melvin Almodovar, Mina Hanna

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Objective N-terminal probrain natriuretic peptide (NT-proBNP) is a biomarker of interest in many cardiopulmonary diseases in extremely low birth weight (ELBW) Infants. However, there is a gap in knowledge about the trend of ELBW infant's urinary NT-proBNP during the neonatal period. Aim To determine the trend of urinary NT-proBNP during the first 4 weeks of life of an ELBW infant. Study Design We analyzed prospectively enrolled 87 ELBW infants. Urinary NT-proBNP to creatinine ratios were measured on days 1 to 7, 14, and 28 of life. We plotted each study point's means to determine the trend of urinary NT-proBNP over the entire neonatal period. Data were analyzed using the Friedman analysis of variance for comparative analysis of study points. Results Urinary NT-proBNP/creatinine ratios were significantly elevated on days 1 to 7 (mean 2,452, ± 1,518) than day 14 (mean 747, ± 176), and day 28 (mean 149, ± 54), p = 0.001. Overall, urinary NT-proBNP levels were highest during days 1 to 3 (mean 3,232, ± 1,255) and lowest on day 28 (mean 149, ± 54). Conclusion Urinary NT-proBNP levels are higher during the first week in ELBW infants with a downward trend during the neonatal period, the lowest values at 4 weeks postnatal age. More studies are required to determine the clinical utility of this trend during and beyond the neonatal period. Key Points NT-proBNP is a biomarker for monitoring cardiac disease in premature infants. The trend of urinary NT-proBNP is unknown in premature infants. A trend of urinary NT-proBNP was determined during the first 4 weeks in premature infants.

Original language	English
Pages (from-to)	1027-1032
Number of pages	6
Journal	American Journal of Perinatology
Volume	39
Issue number	10
DOIs	https://doi.org/10.1055/a-1692-1039
State	Published - Dec 7 2021

Bibliographical note

Publisher Copyright:
© 2021 Thieme Medical Publishers, Inc.. All rights reserved.

Funding

The project described was supported by the National Center for Advancing Translational Sciences, UL1TR000117, the Dean of the College of Medicine, University of Kentucky, and Children’s Miracle Network (CMN) grant awarded to Kentucky Children’s Hospital; U.S. Department of Health and Human Services, National Institutes of Health.

Funders	Funder number
Kentucky Children’s Hospital
National Institutes of Health (NIH)
U.S. Department of Health and Human Services
National Center for Advancing Translational Sciences (NCATS)	UL1TR000117
University of Kentucky
Children's Miracle Network Hospitals

Keywords

NT-proBNP
infants
premature
trend

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/a-1692-1039

Cite this

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title = "The Trend of Urinary N Terminal Probrain Natriuretic Peptide in Extremely Low Birth Weight Infants during the Neonatal Period",

abstract = "Objective N-terminal probrain natriuretic peptide (NT-proBNP) is a biomarker of interest in many cardiopulmonary diseases in extremely low birth weight (ELBW) Infants. However, there is a gap in knowledge about the trend of ELBW infant's urinary NT-proBNP during the neonatal period. Aim To determine the trend of urinary NT-proBNP during the first 4 weeks of life of an ELBW infant. Study Design We analyzed prospectively enrolled 87 ELBW infants. Urinary NT-proBNP to creatinine ratios were measured on days 1 to 7, 14, and 28 of life. We plotted each study point's means to determine the trend of urinary NT-proBNP over the entire neonatal period. Data were analyzed using the Friedman analysis of variance for comparative analysis of study points. Results Urinary NT-proBNP/creatinine ratios were significantly elevated on days 1 to 7 (mean 2,452, ± 1,518) than day 14 (mean 747, ± 176), and day 28 (mean 149, ± 54), p = 0.001. Overall, urinary NT-proBNP levels were highest during days 1 to 3 (mean 3,232, ± 1,255) and lowest on day 28 (mean 149, ± 54). Conclusion Urinary NT-proBNP levels are higher during the first week in ELBW infants with a downward trend during the neonatal period, the lowest values at 4 weeks postnatal age. More studies are required to determine the clinical utility of this trend during and beyond the neonatal period. Key Points NT-proBNP is a biomarker for monitoring cardiac disease in premature infants. The trend of urinary NT-proBNP is unknown in premature infants. A trend of urinary NT-proBNP was determined during the first 4 weeks in premature infants.",

keywords = "NT-proBNP, infants, premature, trend",

author = "Khan, {Safdar S.} and Bada, {Henrietta S.} and Maritza Torres and Melvin Almodovar and Mina Hanna",

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T1 - The Trend of Urinary N Terminal Probrain Natriuretic Peptide in Extremely Low Birth Weight Infants during the Neonatal Period

AU - Khan, Safdar S.

AU - Bada, Henrietta S.

AU - Torres, Maritza

AU - Almodovar, Melvin

AU - Hanna, Mina

PY - 2021/12/7

Y1 - 2021/12/7

N2 - Objective N-terminal probrain natriuretic peptide (NT-proBNP) is a biomarker of interest in many cardiopulmonary diseases in extremely low birth weight (ELBW) Infants. However, there is a gap in knowledge about the trend of ELBW infant's urinary NT-proBNP during the neonatal period. Aim To determine the trend of urinary NT-proBNP during the first 4 weeks of life of an ELBW infant. Study Design We analyzed prospectively enrolled 87 ELBW infants. Urinary NT-proBNP to creatinine ratios were measured on days 1 to 7, 14, and 28 of life. We plotted each study point's means to determine the trend of urinary NT-proBNP over the entire neonatal period. Data were analyzed using the Friedman analysis of variance for comparative analysis of study points. Results Urinary NT-proBNP/creatinine ratios were significantly elevated on days 1 to 7 (mean 2,452, ± 1,518) than day 14 (mean 747, ± 176), and day 28 (mean 149, ± 54), p = 0.001. Overall, urinary NT-proBNP levels were highest during days 1 to 3 (mean 3,232, ± 1,255) and lowest on day 28 (mean 149, ± 54). Conclusion Urinary NT-proBNP levels are higher during the first week in ELBW infants with a downward trend during the neonatal period, the lowest values at 4 weeks postnatal age. More studies are required to determine the clinical utility of this trend during and beyond the neonatal period. Key Points NT-proBNP is a biomarker for monitoring cardiac disease in premature infants. The trend of urinary NT-proBNP is unknown in premature infants. A trend of urinary NT-proBNP was determined during the first 4 weeks in premature infants.

AB - Objective N-terminal probrain natriuretic peptide (NT-proBNP) is a biomarker of interest in many cardiopulmonary diseases in extremely low birth weight (ELBW) Infants. However, there is a gap in knowledge about the trend of ELBW infant's urinary NT-proBNP during the neonatal period. Aim To determine the trend of urinary NT-proBNP during the first 4 weeks of life of an ELBW infant. Study Design We analyzed prospectively enrolled 87 ELBW infants. Urinary NT-proBNP to creatinine ratios were measured on days 1 to 7, 14, and 28 of life. We plotted each study point's means to determine the trend of urinary NT-proBNP over the entire neonatal period. Data were analyzed using the Friedman analysis of variance for comparative analysis of study points. Results Urinary NT-proBNP/creatinine ratios were significantly elevated on days 1 to 7 (mean 2,452, ± 1,518) than day 14 (mean 747, ± 176), and day 28 (mean 149, ± 54), p = 0.001. Overall, urinary NT-proBNP levels were highest during days 1 to 3 (mean 3,232, ± 1,255) and lowest on day 28 (mean 149, ± 54). Conclusion Urinary NT-proBNP levels are higher during the first week in ELBW infants with a downward trend during the neonatal period, the lowest values at 4 weeks postnatal age. More studies are required to determine the clinical utility of this trend during and beyond the neonatal period. Key Points NT-proBNP is a biomarker for monitoring cardiac disease in premature infants. The trend of urinary NT-proBNP is unknown in premature infants. A trend of urinary NT-proBNP was determined during the first 4 weeks in premature infants.

KW - NT-proBNP

KW - infants

KW - premature

KW - trend

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JO - American Journal of Perinatology

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The Trend of Urinary N Terminal Probrain Natriuretic Peptide in Extremely Low Birth Weight Infants during the Neonatal Period

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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