Core Messages: The tumor lysis syndrome (TLS) is a set of metabolic abnormalities caused by widespread tumor cell death and a physiologic inability to maintain adequate clearance rates of tumor metabolites. The cardinal metabolic features of TLS are hyperuricemia, hyperphosphatemia (with secondary hypocalcemia), and hyperkalemia. TLS-induced renal failure is caused by obstructive uric acid and/or calcium phosphate uropathy and can rapidly promote worsening of TLS by further reducing clearance of TLS metabolites. TLS is a life-threatening condition that requires a high level of suspicion, close clinical monitoring, timely therapeutic interventions, and potential involvement of a variety of subspecialty services. Early transfer to the Pediatric Intensive Care Unit to allow close monitoring of the fluid and electrolyte status should be considered in children at high risk for TLS.

Original languageEnglish
Title of host publicationPediatric Nephrology in the ICU
Number of pages18
StatePublished - 2009

ASJC Scopus subject areas

  • General Medicine


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