TY - CHAP
T1 - The tumor lysis syndrome
T2 - An oncologic and metabolic emergency
AU - D'Orazio, J.
PY - 2009
Y1 - 2009
N2 - Core Messages: The tumor lysis syndrome (TLS) is a set of metabolic abnormalities caused by widespread tumor cell death and a physiologic inability to maintain adequate clearance rates of tumor metabolites. The cardinal metabolic features of TLS are hyperuricemia, hyperphosphatemia (with secondary hypocalcemia), and hyperkalemia. TLS-induced renal failure is caused by obstructive uric acid and/or calcium phosphate uropathy and can rapidly promote worsening of TLS by further reducing clearance of TLS metabolites. TLS is a life-threatening condition that requires a high level of suspicion, close clinical monitoring, timely therapeutic interventions, and potential involvement of a variety of subspecialty services. Early transfer to the Pediatric Intensive Care Unit to allow close monitoring of the fluid and electrolyte status should be considered in children at high risk for TLS.
AB - Core Messages: The tumor lysis syndrome (TLS) is a set of metabolic abnormalities caused by widespread tumor cell death and a physiologic inability to maintain adequate clearance rates of tumor metabolites. The cardinal metabolic features of TLS are hyperuricemia, hyperphosphatemia (with secondary hypocalcemia), and hyperkalemia. TLS-induced renal failure is caused by obstructive uric acid and/or calcium phosphate uropathy and can rapidly promote worsening of TLS by further reducing clearance of TLS metabolites. TLS is a life-threatening condition that requires a high level of suspicion, close clinical monitoring, timely therapeutic interventions, and potential involvement of a variety of subspecialty services. Early transfer to the Pediatric Intensive Care Unit to allow close monitoring of the fluid and electrolyte status should be considered in children at high risk for TLS.
UR - http://www.scopus.com/inward/record.url?scp=80054725984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80054725984&partnerID=8YFLogxK
U2 - 10.1007/978-3-540-74425-2_15
DO - 10.1007/978-3-540-74425-2_15
M3 - Chapter
AN - SCOPUS:80054725984
SN - 9783540744238
SP - 201
EP - 218
BT - Pediatric Nephrology in the ICU
ER -