The ubiquitin-proteasome pathway and proteasome inhibitors

Jayhyuk Myung, Kyung Bo Kim, Craig M. Crews

Research output: Contribution to journalReview articlepeer-review

359 Scopus citations

Abstract

The ubiquitin-proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various components of the ubiquitin-proteasome pathway. In addition, this review covers the chemistry of synthetic and natural proteasome inhibitors, emphasizing their mode of actions toward the 20S proteasome. Given the importance of proteasome-mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases.

Original languageEnglish
Pages (from-to)245-273
Number of pages29
JournalMedicinal Research Reviews
Volume21
Issue number4
DOIs
StatePublished - 2001

Keywords

  • Natural product
  • Proteasome inhibitor
  • Protein degradation
  • Ubiquitin-proteasome pathway

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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