The Use of Saccharomyces cerevisiae to Study the Mechanism of pre-mRNA Splicing

Brian C. Rymond

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

• The core spliceosome is highly conserved between Saccharomyces cerevisiae and humans. • Yeast contains fewer introns that humans, but these introns are in highly expressed genes, including ribosomal genes. • Yeast splicing occurs by intron definition. • The yeast spliceosome can be studied by genetic approaches that allow the rapid identification of spliceosomal components and their interacting partners.

Original languageEnglish
Title of host publicationAlternative pre-mRNA Splicing
Subtitle of host publicationTheory and Protocols
Pages65-77
Number of pages13
DOIs
StatePublished - Feb 2 2012

Keywords

  • Genetic interaction maps
  • Genome-wide studies
  • Spliceosome
  • Suppressor analysis
  • Synthetic lethality
  • Yeast genetics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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