The Use of Saccharomyces cerevisiae to Study the Mechanism of pre-mRNA Splicing

Brian C. Rymond

doi:10.1002/9783527636778.ch6

The Use of Saccharomyces cerevisiae to Study the Mechanism of pre-mRNA Splicing

Brian C. Rymond

Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

• The core spliceosome is highly conserved between Saccharomyces cerevisiae and humans. • Yeast contains fewer introns that humans, but these introns are in highly expressed genes, including ribosomal genes. • Yeast splicing occurs by intron definition. • The yeast spliceosome can be studied by genetic approaches that allow the rapid identification of spliceosomal components and their interacting partners.

Original language	English
Title of host publication	Alternative pre-mRNA Splicing
Subtitle of host publication	Theory and Protocols
Pages	65-77
Number of pages	13
DOIs	https://doi.org/10.1002/9783527636778.ch6
State	Published - Feb 2 2012

Keywords

Genetic interaction maps
Genome-wide studies
Spliceosome
Suppressor analysis
Synthetic lethality
Yeast genetics

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1002/9783527636778.ch6

Cite this

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KW - Suppressor analysis

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The Use of Saccharomyces cerevisiae to Study the Mechanism of pre-mRNA Splicing

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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