The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy

Benjamin I. Burke, Ahmed Ismaeel, John J. McCarthy

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Skeletal muscle exhibits remarkable plasticity to adapt to stimuli such as mechanical loading. The mechanisms that regulate skeletal muscle hypertrophy due to mechanical overload have been thoroughly studied. Remarkably, our understanding of many of the molecular and cellular mechanisms that regulate hypertrophic growth were first identified using the rodent synergist ablation (SA) model and subsequently corroborated in human resistance exercise training studies. To demonstrate the utility of the SA model, we briefly summarize the hypertrophic mechanisms identified using the model and the following translation of these mechanism to human skeletal muscle hypertrophy induced by resistance exercise training.

Original languageEnglish
Pages (from-to)C601-C606
JournalAmerican Journal of Physiology - Cell Physiology
Volume327
Issue number3
DOIs
StatePublished - Aug 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors.

Keywords

  • microRNAs
  • mTOR signaling
  • protein synthesis
  • ribosome biogenesis
  • satellite cell fusion

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Fingerprint

Dive into the research topics of 'The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy'. Together they form a unique fingerprint.

Cite this