TY - JOUR
T1 - The utility of the rodent synergist ablation model in identifying molecular and cellular mechanisms of skeletal muscle hypertrophy
AU - Burke, Benjamin I.
AU - Ismaeel, Ahmed
AU - McCarthy, John J.
N1 - Publisher Copyright:
© 2024 The Authors.
PY - 2024/8
Y1 - 2024/8
N2 - Skeletal muscle exhibits remarkable plasticity to adapt to stimuli such as mechanical loading. The mechanisms that regulate skeletal muscle hypertrophy due to mechanical overload have been thoroughly studied. Remarkably, our understanding of many of the molecular and cellular mechanisms that regulate hypertrophic growth were first identified using the rodent synergist ablation (SA) model and subsequently corroborated in human resistance exercise training studies. To demonstrate the utility of the SA model, we briefly summarize the hypertrophic mechanisms identified using the model and the following translation of these mechanism to human skeletal muscle hypertrophy induced by resistance exercise training.
AB - Skeletal muscle exhibits remarkable plasticity to adapt to stimuli such as mechanical loading. The mechanisms that regulate skeletal muscle hypertrophy due to mechanical overload have been thoroughly studied. Remarkably, our understanding of many of the molecular and cellular mechanisms that regulate hypertrophic growth were first identified using the rodent synergist ablation (SA) model and subsequently corroborated in human resistance exercise training studies. To demonstrate the utility of the SA model, we briefly summarize the hypertrophic mechanisms identified using the model and the following translation of these mechanism to human skeletal muscle hypertrophy induced by resistance exercise training.
KW - microRNAs
KW - mTOR signaling
KW - protein synthesis
KW - ribosome biogenesis
KW - satellite cell fusion
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U2 - 10.1152/ajpcell.00362.2024
DO - 10.1152/ajpcell.00362.2024
M3 - Review article
C2 - 39069822
AN - SCOPUS:85202087847
SN - 0363-6143
VL - 327
SP - C601-C606
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
IS - 3
ER -