The Wnt/β-Catenin Pathway

C. Liu; Y. Regimbald-Dumas; X. Zhang; X. He

doi:10.1016/B978-0-12-394447-4.30008-6

The Wnt/β-Catenin Pathway

C. Liu, Y. Regimbald-Dumas, X. Zhang, X. He

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Signaling by the secreted Wnt family of lipoglycoproteins has central and conserved roles in animal development, tissue homeostasis, stem cell regulation, and pathogenesis of cancer and other diseases. This article provides an overview of the canonical Wnt signaling pathway, which acts through stabilization of the transcriptional co-activator β-catenin, thereby governing gene expression programs.

Original language	English
Title of host publication	Functional Cell Biology
Pages	86-98
Number of pages	13
Volume	3
ISBN (Electronic)	9780123944474
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30008-6
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.

Keywords

Adenomatous polyposis coli (APC)
Agonists
Antagonists
Axin
LEF
Receptor/coreceptor
Signaling
Tcf
Transcription
Wnt
β-Catenin

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-394447-4.30008-6

Cite this

@inbook{abc4cd21f03a43d38cc00ab036861ede,

title = "The Wnt/β-Catenin Pathway",

abstract = "Signaling by the secreted Wnt family of lipoglycoproteins has central and conserved roles in animal development, tissue homeostasis, stem cell regulation, and pathogenesis of cancer and other diseases. This article provides an overview of the canonical Wnt signaling pathway, which acts through stabilization of the transcriptional co-activator β-catenin, thereby governing gene expression programs.",

keywords = "Adenomatous polyposis coli (APC), Agonists, Antagonists, Axin, LEF, Receptor/coreceptor, Signaling, Tcf, Transcription, Wnt, β-Catenin",

author = "C. Liu and Y. Regimbald-Dumas and X. Zhang and X. He",

year = "2016",

doi = "10.1016/B978-0-12-394447-4.30008-6",

language = "English",

isbn = "9780123947963",

volume = "3",

pages = "86--98",

booktitle = "Functional Cell Biology",

}

TY - CHAP

T1 - The Wnt/β-Catenin Pathway

AU - Liu, C.

AU - Regimbald-Dumas, Y.

AU - Zhang, X.

AU - He, X.

PY - 2016

Y1 - 2016

N2 - Signaling by the secreted Wnt family of lipoglycoproteins has central and conserved roles in animal development, tissue homeostasis, stem cell regulation, and pathogenesis of cancer and other diseases. This article provides an overview of the canonical Wnt signaling pathway, which acts through stabilization of the transcriptional co-activator β-catenin, thereby governing gene expression programs.

AB - Signaling by the secreted Wnt family of lipoglycoproteins has central and conserved roles in animal development, tissue homeostasis, stem cell regulation, and pathogenesis of cancer and other diseases. This article provides an overview of the canonical Wnt signaling pathway, which acts through stabilization of the transcriptional co-activator β-catenin, thereby governing gene expression programs.

KW - Adenomatous polyposis coli (APC)

KW - Agonists

KW - Antagonists

KW - Axin

KW - LEF

KW - Receptor/coreceptor

KW - Signaling

KW - Tcf

KW - Transcription

KW - Wnt

KW - β-Catenin

UR - http://www.scopus.com/inward/record.url?scp=85042778517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042778517&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394447-4.30008-6

DO - 10.1016/B978-0-12-394447-4.30008-6

M3 - Chapter

AN - SCOPUS:85042778517

SN - 9780123947963

VL - 3

SP - 86

EP - 98

BT - Functional Cell Biology

ER -

The Wnt/β-Catenin Pathway

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this