The Wnt/β-Catenin Pathway

C. Liu, Y. Regimbald-Dumas, X. Zhang, X. He

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations


Signaling by the secreted Wnt family of lipoglycoproteins has central and conserved roles in animal development, tissue homeostasis, stem cell regulation, and pathogenesis of cancer and other diseases. This article provides an overview of the canonical Wnt signaling pathway, which acts through stabilization of the transcriptional co-activator β-catenin, thereby governing gene expression programs.

Original languageEnglish
Title of host publicationFunctional Cell Biology
Number of pages13
ISBN (Electronic)9780123944474
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.


  • Adenomatous polyposis coli (APC)
  • Agonists
  • Antagonists
  • Axin
  • LEF
  • Receptor/coreceptor
  • Signaling
  • Tcf
  • Transcription
  • Wnt
  • β-Catenin

ASJC Scopus subject areas

  • General Medicine


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