Thematic review series: The immune system and atherogenesis. Cytokine regulation of macrophage functions in atherogenesis

Alan Daugherty, Nancy R. Webb, Debra L. Rateri, Victoria L. King

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

This review will focus on the role of cytokines in the behavior of macrophages, a prominent cell type of atherosclerotic lesions. Once these macrophages have immigrated into the vessel wall, they propagate the development of atherosclerosis by modifying lipoproteins, accumulating intracellular lipids, remodeling the extracellular environment, and promoting local coagulation. The numerous cytokines that have been detected in atherosclerosis, combined with the expression of large numbers of cytokine receptors on macrophages, are consistent with this axis being an important contributor to lesion development. Given the vast literature on cytokine-macrophage interactions, this review will be selective, with an emphasis on the major cytokines thai have been detected in atherosclerotic lesions and their effects on properties that are relevant to lesion formation and maturation. There will be an emphasis on the role of cytokines in regulating lipid metabolism by macrophages. We will provide an overview of the major findings in cell culture and then put these in the context of in vivo studies.

Original languageEnglish
Pages (from-to)1812-1822
Number of pages11
JournalJournal of Lipid Research
Volume46
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Coagulation
  • Lipoprotein
  • Matrix
  • Metabolism
  • Modification

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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