Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

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20 Scopus citations

Abstract

Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.

Original languageEnglish
Pages (from-to)416-424
Number of pages9
JournalNeural Regeneration Research
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2020

Bibliographical note

Funding Information:
Funding: This work was supported by AHA Award 14SDG20480186 (to LC), Kentucky Spinal Cord & Head Injury Research Trust Grant 14-12A (to KES), Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators (1410170078) (to BZ).

Funding Information:
Author contributions: All authors wrote the manuscript. LC approved the final manuscript. Conflicts of interest: We declare no conflicts of interest. Financial support: This work was supported by AHA Award 14SDG20480186 (to LC), Kentucky Spinal Cord & Head Injury Research Trust Grant 14-12A (to KES), Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators (1410170078) (to BZ). Copyright license agreement: The Copyright License Agreement has been signed by all authors before publication. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.

Keywords

  • Cell death
  • Herbal compound
  • Immune response
  • Ischemic stroke therapy
  • Neuroplasticity
  • Neuroprotection
  • Oxidative damage
  • Traditional Chinese medicine

ASJC Scopus subject areas

  • Developmental Neuroscience

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