Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

Bei Zhang; Kathryn Saatman; Lei Chen

doi:10.4103/1673-5374.265545

Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

Bei Zhang, Kathryn Saatman, Lei Chen

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.

Original language	English
Pages (from-to)	416-424
Number of pages	9
Journal	Neural Regeneration Research
Volume	15
Issue number	3
DOIs	https://doi.org/10.4103/1673-5374.265545
State	Published - Mar 1 2020

Bibliographical note

Funding Information:
Funding: This work was supported by AHA Award 14SDG20480186 (to LC), Kentucky Spinal Cord & Head Injury Research Trust Grant 14-12A (to KES), Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators (1410170078) (to BZ).

Funding Information:
Author contributions: All authors wrote the manuscript. LC approved the final manuscript. Conflicts of interest: We declare no conflicts of interest. Financial support: This work was supported by AHA Award 14SDG20480186 (to LC), Kentucky Spinal Cord & Head Injury Research Trust Grant 14-12A (to KES), Startup Funds from Shaanxi University of Chinese Medicine to Young Investigators (1410170078) (to BZ). Copyright license agreement: The Copyright License Agreement has been signed by all authors before publication. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

Publisher Copyright:
© 2020 Wolters Kluwer Medknow Publications. All rights reserved.

Keywords

Cell death
Herbal compound
Immune response
Ischemic stroke therapy
Neuroplasticity
Neuroprotection
Oxidative damage
Traditional Chinese medicine

ASJC Scopus subject areas

Developmental Neuroscience

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10.4103/1673-5374.265545

Cite this

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title = "Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke",

abstract = "Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs, especially those used in Chinese medicine, have emerged as new pharmaceuticals for stroke treatment. Here we review the evidence from preclinical studies investigating neuroprotective properties of Chinese medicinal compounds through their application in acute and subacute phases of ischemic stroke, and highlight potential mechanisms underlying their therapeutic effects. It is noteworthy that many herbal compounds have been shown to target multiple mechanisms and in combinations may exert synergistic effects on signaling pathways, thereby attenuating multiple aspects of ischemic pathology. We conclude the paper with a general discussion of the prospects for novel natural compound-based regimens against stroke.",

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Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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