Thermally responsive membrane-based microbiological sensing component for early detection of membrane biofouling

Guang Cai; Colleen Gorey; Amr Zaky; Isabel Escobar; Cyndee Gruden

doi:10.1016/j.desal.2010.11.030

Thermally responsive membrane-based microbiological sensing component for early detection of membrane biofouling

Guang Cai, Colleen Gorey, Amr Zaky, Isabel Escobar, Cyndee Gruden

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Early detection of bacteria in water treatment is desired to mitigate system biofouling and potential human health impacts. This research involved the development of an antibody-based sensor, which was attached to a hydroxypropyl cellulose (HPC) modified cellulose acetate ultrafiltration membrane surface, to target bacteria. HPC was chosen because it collapses above and expands below a lower critical solution temperature (43. °C), thus allowing temperature modulation. The membrane had a high target recovery efficiency (10-18%) in both single bacterium and complex samples (simulated by adding organics and competitive organisms). Sensor recovery was decreased (to 5-7%) following temperature activation (above 50. °C) due to adverse impacts of temperature on the antibody. The membrane was able to be regenerated (with 0.1. M NaOH) and reused three consecutive times. The thermally responsive sensing membrane developed from this work was specifically developed to detect biofoulants in membrane-based water treatment processes. However, it could be adapted to address a range of environmental detection concerns, such as pathogen detection.

Original language	English
Pages (from-to)	116-123
Number of pages	8
Journal	Desalination
Volume	270
Issue number	1-3
DOIs	https://doi.org/10.1016/j.desal.2010.11.030
State	Published - Apr 1 2011

Bibliographical note

Funding Information:
We are grateful to DARPA (Grant HR0011-07-1-0003 ) and NSF (CBET 0610624 ) for funding this research. We also wish to express our sincere thanks to Dr Steven Kloos and Ms Jessica Schloss of GE water and Process Technologies for providing membranes.

Funding

We are grateful to DARPA (Grant HR0011-07-1-0003 ) and NSF (CBET 0610624 ) for funding this research. We also wish to express our sincere thanks to Dr Steven Kloos and Ms Jessica Schloss of GE water and Process Technologies for providing membranes.

Funders	Funder number
National Science Foundation (NSF)	CBET 0610624
Defense Advanced Research Projects Agency	HR0011-07-1-0003

Keywords

Antibody
Detection
Membrane
Sensor

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering
General Materials Science
Water Science and Technology
Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.desal.2010.11.030

Cite this

@article{7e0fc439f6e742dca2ac4e27ab0d019a,

title = "Thermally responsive membrane-based microbiological sensing component for early detection of membrane biofouling",

abstract = "Early detection of bacteria in water treatment is desired to mitigate system biofouling and potential human health impacts. This research involved the development of an antibody-based sensor, which was attached to a hydroxypropyl cellulose (HPC) modified cellulose acetate ultrafiltration membrane surface, to target bacteria. HPC was chosen because it collapses above and expands below a lower critical solution temperature (43. °C), thus allowing temperature modulation. The membrane had a high target recovery efficiency (10-18\%) in both single bacterium and complex samples (simulated by adding organics and competitive organisms). Sensor recovery was decreased (to 5-7\%) following temperature activation (above 50. °C) due to adverse impacts of temperature on the antibody. The membrane was able to be regenerated (with 0.1. M NaOH) and reused three consecutive times. The thermally responsive sensing membrane developed from this work was specifically developed to detect biofoulants in membrane-based water treatment processes. However, it could be adapted to address a range of environmental detection concerns, such as pathogen detection.",

keywords = "Antibody, Detection, Membrane, Sensor",

author = "Guang Cai and Colleen Gorey and Amr Zaky and Isabel Escobar and Cyndee Gruden",

note = "Funding Information: We are grateful to DARPA (Grant HR0011-07-1-0003 ) and NSF (CBET 0610624 ) for funding this research. We also wish to express our sincere thanks to Dr Steven Kloos and Ms Jessica Schloss of GE water and Process Technologies for providing membranes.",

year = "2011",

month = apr,

day = "1",

doi = "10.1016/j.desal.2010.11.030",

language = "English",

volume = "270",

pages = "116--123",

number = "1-3",

}

TY - JOUR

T1 - Thermally responsive membrane-based microbiological sensing component for early detection of membrane biofouling

AU - Cai, Guang

AU - Gorey, Colleen

AU - Zaky, Amr

AU - Escobar, Isabel

AU - Gruden, Cyndee

N1 - Funding Information: We are grateful to DARPA (Grant HR0011-07-1-0003 ) and NSF (CBET 0610624 ) for funding this research. We also wish to express our sincere thanks to Dr Steven Kloos and Ms Jessica Schloss of GE water and Process Technologies for providing membranes.

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Early detection of bacteria in water treatment is desired to mitigate system biofouling and potential human health impacts. This research involved the development of an antibody-based sensor, which was attached to a hydroxypropyl cellulose (HPC) modified cellulose acetate ultrafiltration membrane surface, to target bacteria. HPC was chosen because it collapses above and expands below a lower critical solution temperature (43. °C), thus allowing temperature modulation. The membrane had a high target recovery efficiency (10-18%) in both single bacterium and complex samples (simulated by adding organics and competitive organisms). Sensor recovery was decreased (to 5-7%) following temperature activation (above 50. °C) due to adverse impacts of temperature on the antibody. The membrane was able to be regenerated (with 0.1. M NaOH) and reused three consecutive times. The thermally responsive sensing membrane developed from this work was specifically developed to detect biofoulants in membrane-based water treatment processes. However, it could be adapted to address a range of environmental detection concerns, such as pathogen detection.

AB - Early detection of bacteria in water treatment is desired to mitigate system biofouling and potential human health impacts. This research involved the development of an antibody-based sensor, which was attached to a hydroxypropyl cellulose (HPC) modified cellulose acetate ultrafiltration membrane surface, to target bacteria. HPC was chosen because it collapses above and expands below a lower critical solution temperature (43. °C), thus allowing temperature modulation. The membrane had a high target recovery efficiency (10-18%) in both single bacterium and complex samples (simulated by adding organics and competitive organisms). Sensor recovery was decreased (to 5-7%) following temperature activation (above 50. °C) due to adverse impacts of temperature on the antibody. The membrane was able to be regenerated (with 0.1. M NaOH) and reused three consecutive times. The thermally responsive sensing membrane developed from this work was specifically developed to detect biofoulants in membrane-based water treatment processes. However, it could be adapted to address a range of environmental detection concerns, such as pathogen detection.

KW - Antibody

KW - Detection

KW - Membrane

KW - Sensor

UR - http://www.scopus.com/inward/record.url?scp=79951677096&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951677096&partnerID=8YFLogxK

U2 - 10.1016/j.desal.2010.11.030

DO - 10.1016/j.desal.2010.11.030

M3 - Article

AN - SCOPUS:79951677096

SN - 0011-9164

VL - 270

SP - 116

EP - 123

JO - Desalination

JF - Desalination

IS - 1-3

ER -

Thermally responsive membrane-based microbiological sensing component for early detection of membrane biofouling

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this