Thiazolidine and thiazoline derivatives of 3-aryl-3-trifluoromethyldiazirines for the preparation of fluorescent or 35S-radiolabeled photoaffinity probes

Stefan Kwiatkowski, Peter J. Crocker, Ashok J. Chavan, Imai Nobuyuki, Boyd E. Haley, David S. Watt, Ho Ren-jye

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The condensation of cysteine with 3-(4-formylphenyl) or 3-(4-cyanophenyl)-3-trifluoromethyldiazirine furnished thiazolidine and thiazoline derivatives in good yield. These heterocycles provide convenient access to photoaffinity probes an 35S radiolabel or a fluorescent dansyl group.

Original languageEnglish
Pages (from-to)2093-2096
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number15
DOIs
StatePublished - 1990

Bibliographical note

Funding Information:
We thank the National.Institutes financial support.

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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