Thiazolidine and thiazoline derivatives of 3-aryl-3-trifluoromethyldiazirines for the preparation of fluorescent or 35S-radiolabeled photoaffinity probes

Stefan Kwiatkowski; Peter J. Crocker; Ashok J. Chavan; Imai Nobuyuki; Boyd E. Haley; David S. Watt; Ho Ren-jye

doi:10.1016/0040-4039(90)80080-6

Thiazolidine and thiazoline derivatives of 3-aryl-3-trifluoromethyldiazirines for the preparation of fluorescent or ³⁵S-radiolabeled photoaffinity probes

Stefan Kwiatkowski
, Peter J. Crocker
, Ashok J. Chavan
, Imai Nobuyuki
, Boyd E. Haley
, David S. Watt
, Ho Ren-jye

Molecular and Cellular Biochemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The condensation of cysteine with 3-(4-formylphenyl) or 3-(4-cyanophenyl)-3-trifluoromethyldiazirine furnished thiazolidine and thiazoline derivatives in good yield. These heterocycles provide convenient access to photoaffinity probes an ³⁵S radiolabel or a fluorescent dansyl group.

Original language	English
Pages (from-to)	2093-2096
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	15
DOIs	https://doi.org/10.1016/0040-4039(90)80080-6
State	Published - 1990

Bibliographical note

Funding Information:
We thank the National.Institutes financial support.

Funding

We thank the National.Institutes financial support.

Funders
National.Institutes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/0040-4039(90)80080-6

Cite this

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title = "Thiazolidine and thiazoline derivatives of 3-aryl-3-trifluoromethyldiazirines for the preparation of fluorescent or 35S-radiolabeled photoaffinity probes",

abstract = "The condensation of cysteine with 3-(4-formylphenyl) or 3-(4-cyanophenyl)-3-trifluoromethyldiazirine furnished thiazolidine and thiazoline derivatives in good yield. These heterocycles provide convenient access to photoaffinity probes an 35S radiolabel or a fluorescent dansyl group.",

author = "Stefan Kwiatkowski and Crocker, \{Peter J.\} and Chavan, \{Ashok J.\} and Imai Nobuyuki and Haley, \{Boyd E.\} and Watt, \{David S.\} and Ho Ren-jye",

note = "Funding Information: We thank the National.Institutes financial support.",

year = "1990",

doi = "10.1016/0040-4039(90)80080-6",

language = "English",

volume = "31",

pages = "2093--2096",

number = "15",

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T1 - Thiazolidine and thiazoline derivatives of 3-aryl-3-trifluoromethyldiazirines for the preparation of fluorescent or 35S-radiolabeled photoaffinity probes

AU - Kwiatkowski, Stefan

AU - Crocker, Peter J.

AU - Chavan, Ashok J.

AU - Nobuyuki, Imai

AU - Haley, Boyd E.

AU - Watt, David S.

AU - Ren-jye, Ho

N1 - Funding Information: We thank the National.Institutes financial support.

PY - 1990

Y1 - 1990

N2 - The condensation of cysteine with 3-(4-formylphenyl) or 3-(4-cyanophenyl)-3-trifluoromethyldiazirine furnished thiazolidine and thiazoline derivatives in good yield. These heterocycles provide convenient access to photoaffinity probes an 35S radiolabel or a fluorescent dansyl group.

AB - The condensation of cysteine with 3-(4-formylphenyl) or 3-(4-cyanophenyl)-3-trifluoromethyldiazirine furnished thiazolidine and thiazoline derivatives in good yield. These heterocycles provide convenient access to photoaffinity probes an 35S radiolabel or a fluorescent dansyl group.

UR - https://www.scopus.com/pages/publications/0025255952

UR - https://www.scopus.com/pages/publications/0025255952#tab=citedBy

U2 - 10.1016/0040-4039(90)80080-6

DO - 10.1016/0040-4039(90)80080-6

M3 - Article

AN - SCOPUS:0025255952

SN - 0040-4039

VL - 31

SP - 2093

EP - 2096

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 15

ER -