Abstract
The synthesis of a 3β‐thiocyanatocardenolide is described. The compound exhibited about 0.1 times the cardiotonic effect of digitoxigenin in the isolated frog heart preparation. At a dosage of 20 mg/kg in the intact rat, it elicited ECG changes similar to those seen with a 10‐mg/kg dose of digitoxigenin. Studies also revealed the new cardenolide to be a reversible inhibitor of sodium‐ and potassium‐activated adenosine triphosphatase.
Original language | English |
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Pages (from-to) | 765-768 |
Number of pages | 4 |
Journal | Journal of Pharmaceutical Sciences |
Volume | 65 |
Issue number | 5 |
DOIs | |
State | Published - May 1976 |
Keywords
- Adenosine triphosphatase, sodium and potassium activated—effect of 3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide evaluated
- Cardiotonic agents, potential—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide synthesized and screened
- Thiocardenolides—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide synthesized, screened for cardiotonic activity and effect on sodium‐ and potassium‐activated adenosine triphosphatase
ASJC Scopus subject areas
- Pharmaceutical Science