Thiocardenolides I: Synthesis and biological actions of 3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide

Hanley N. Abramson, Chian L. Huang, Thomas F. Wu, Thomas Tobin

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The synthesis of a 3β‐thiocyanatocardenolide is described. The compound exhibited about 0.1 times the cardiotonic effect of digitoxigenin in the isolated frog heart preparation. At a dosage of 20 mg/kg in the intact rat, it elicited ECG changes similar to those seen with a 10‐mg/kg dose of digitoxigenin. Studies also revealed the new cardenolide to be a reversible inhibitor of sodium‐ and potassium‐activated adenosine triphosphatase.

Original languageEnglish
Pages (from-to)765-768
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number5
StatePublished - May 1976


  • Adenosine triphosphatase, sodium and potassium activated—effect of 3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide evaluated
  • Cardiotonic agents, potential—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide synthesized and screened
  • Thiocardenolides—3β‐thiocyanato‐14β‐hydroxy‐5β‐card‐20(22)‐enolide synthesized, screened for cardiotonic activity and effect on sodium‐ and potassium‐activated adenosine triphosphatase

ASJC Scopus subject areas

  • Pharmaceutical Science


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