Three-dimensional Echocardiographic Volume Computation: In Vitro Comparison to Standard Two-dimensional Echocardiography

Klaus M. Schröder, Peter M. Sapin, Donald L. King, Mikel D. Smith, Anthony N. DeMaria

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Two-dimensional (2D) echocardiographic methods for quantitative left ventricular volume computation have been shown to have a low predictive accuracy and reproducibility. To address the problem of geometric assumptions and image plane positioning errors inherent in 2D echocardiography, three-dimensional (3D) echocardiographic systems have been constructed that provide spatial registration and display of transducer-image position and orientation. Although 3D echocardiography has been shown to accurately measure volume in vitro and in vivo, only preliminary data exist demonstrating its superiority over standard 2D echocardiography. We calculated the volume of 30 water-filled latex balloon phantoms of varying size (40 to 200 ml) and shape using each method. Fifteen phantoms were nondistorted (ellipsoid or pear shaped); 15 were symmetrically distorted (dumbbell shaped). Although both 2D and 3D echocardiography showed an excellent correlation to the true volume 2.650 ± 1.90, respectively). We conclude that 3D echocardiography with guided image plane positioning and a novel algorithm for volume computation (polyhedral surface reconstruction) achieves s' ' cantly more accurate and reproducible results than conventional 2D echocardiography with the modified Simpson's rule. 3D echocardiography therefore has the potential for becoming a more exact and reproducible method for serial quantitative volume determination.

Original languageEnglish
Pages (from-to)467-475
Number of pages9
JournalJournal of the American Society of Echocardiography
Issue number5
StatePublished - 1993

Bibliographical note

Funding Information:
From the University of Kenmcky and Columbia University. Klaus M. SchrOder was supported by a grant from the Deutsche Forschungsgemeinschafr (Bonn, Germany). This work was presented in part at the Third Annual Scientific Meeting of the American Society of Echocardiography, June 15-17, 1992, Boston, Massachusetts.

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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