Three-dimensional flow contrast imaging of deep tissue using noncontact diffuse correlation tomography

Yu Lin, Chong Huang, Daniel Irwin, Lian He, Yu Shang, Guoqiang Yu

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

This study extended our recently developed noncontact diffuse correlation spectroscopy flowmetry system into noncontact diffuse correlation tomography (ncDCT) for three-dimensional (3-D) flow imaging of deep tissue. A linear array of 15 photodetectors and two laser sources connected to a mobile lens-focusing system enabled automatic and noncontact scanning of flow in a region of interest. These boundary measurements were combined with a finite element framework for DCT image reconstruction implemented into an existing software package. This technique was tested in computer simulations and using a tissue-like phantom with anomaly flow contrast design. The cylindrical tube-shaped anomaly was clearly reconstructed in both simulation and phantom. Recovered and assigned flow contrast changes in anomaly were found to be highly correlated: regression slope = 1.00, R2 = 1.00, and p < 10 -5 in simulation and regression slope ≥ 0.97, R2 ≥ 0.96, and p < 10-3 in phantom. These results exhibit promise of our ncDCT technique for 3-D imaging of deep tissue blood flow heterogeneities.

Original languageEnglish
Article number121103
JournalApplied Physics Letters
Volume104
Issue number12
DOIs
StatePublished - Mar 24 2014

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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