Three equine cases of mixed hepatoblastoma with teratoid features

Alan T. Loynachan, D. C. Bolin, C. B. Hong, K. B. Poonacha

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Hepatoblastoma was diagnosed in 3 Thoroughbreds at the University of Kentucky Livestock Disease Diagnostic Center (LDDC) since 1997. Case #1 involved a fetus with a well-demarcated, multilobulated, solitary mass that extended from the left liver lobe. Case #2 was observed in a neonate with a primary hepatic mass and multiple metastases in the skin, brain, meninges, and stylohyoid bone. Case #3 was a solitary hepatic mass incidentally discovered in a neonate at necropsy. Microscopically, the masses were similarly composed of sheets and cords of fetal and embryonal epithelial cells that frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells were variable amounts of hemorrhage, necrosis, osteoid, and bone. Immunohistochemically, the epithelial cells stained variably positive for alpha- fetoprotein, frequently positive for vimentin, and occasionally positive for cytokeratin. All 3 cases were diagnosed as mixed hepatoblastoma with teratoid features.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalVeterinary Pathology
Issue number2
StatePublished - Mar 2007


  • Equine
  • Fetus
  • Hepatoblastoma
  • Metastases
  • Mixed
  • Neonate
  • Teratoid

ASJC Scopus subject areas

  • Veterinary (all)


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