TY - JOUR
T1 - Three months of chronic ethanol administration and the behavioral outcome of rats after lateral fluid percussion brain injury
AU - Masse, James
AU - Billings, Barry
AU - Dhillon, Harabhajan S.
AU - Mace, Derek
AU - Hicks, Ramona
AU - Barron, Susan
AU - Kraemer, Phillip J.
AU - Dendle, Peter
AU - Prasad, Renuka M.
PY - 2000/5
Y1 - 2000/5
N2 - This study examined the effects of 3 months of chronic ethanol administration (CEAn) on the behavioral outcome in rats after lateral fluid percussion (FP) brain injury. Rats were given either an ethanol liquid diet (ethanol diet groups) or a pair-fed isocaloric sucrose control diet (control diet groups) for 3 months. Then, rats from both diet groups were subjected to either lateral FP brain injury of moderate severity (1.8 atm) or to sham operation. Postinjury behavioral measurements revealed that brain injury caused significant spatial learning disability in both diet groups. There were no significant differences in spatial learning ability in the sham or brain-injured animals between the control and ethanol diets. However, a trend towards cognitive impairment in the sham animals and a trend towards reduced deficits in the brain-injured animals were observed in the ethanol diet group. Histologic analysis of injured animals from both diet groups revealed similar extents of ipsilateral cortical and hippocampal CA3 damage. These results, in general, suggest that 3 months of CEAn does not significantly alter the behavioral and morphologic outcome of experimental brain injury.
AB - This study examined the effects of 3 months of chronic ethanol administration (CEAn) on the behavioral outcome in rats after lateral fluid percussion (FP) brain injury. Rats were given either an ethanol liquid diet (ethanol diet groups) or a pair-fed isocaloric sucrose control diet (control diet groups) for 3 months. Then, rats from both diet groups were subjected to either lateral FP brain injury of moderate severity (1.8 atm) or to sham operation. Postinjury behavioral measurements revealed that brain injury caused significant spatial learning disability in both diet groups. There were no significant differences in spatial learning ability in the sham or brain-injured animals between the control and ethanol diets. However, a trend towards cognitive impairment in the sham animals and a trend towards reduced deficits in the brain-injured animals were observed in the ethanol diet group. Histologic analysis of injured animals from both diet groups revealed similar extents of ipsilateral cortical and hippocampal CA3 damage. These results, in general, suggest that 3 months of CEAn does not significantly alter the behavioral and morphologic outcome of experimental brain injury.
KW - Behavioral deficits
KW - Chronic ethanol administration
KW - Fluid percussion brain injury
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U2 - 10.1089/neu.2000.17.421
DO - 10.1089/neu.2000.17.421
M3 - Article
C2 - 10833061
AN - SCOPUS:0034076407
VL - 17
SP - 421
EP - 430
IS - 5
ER -