TY - JOUR
T1 - Three new unsaturated fatty acids from the marine green alga ulva fasciata delile
AU - Abou-ElWafa, Ghada S.E.
AU - Shaaban, Mohamed
AU - Shaaban, Khaled A.
AU - El-Naggar, Mohamed E.E.
AU - Laatsch, Hartmut
PY - 2009
Y1 - 2009
N2 - From the dichloromethane extract of the marine green alga Ulva fasciata Delile, collected from the Mediterranean coast of Egypt, three new fatty acids, namely, (E)-11-oxo-octadeca-12-enoic acid (1a), (E)-11-hydroxy-octadeca-12-enoic acid (2a) and 6-hydroxy-oct-7-enoic acid (3a) together with cholesterol were isolated. Analysis of the unpolar part of the extract using GC-MS detected the existence of further ten compounds, namely, dimethylsulfoxide, dimethylsulfone, phenylacetamide, 6,10,14-trimethyl-pentadecan-2-one, 8-heptadecene, dodecane, tridecane, 4-oxo-pentanoic acid, hexadecanoic acid, and the naturally new 1,1'-bicyclohexyl. Structures of the isolated compounds 1a - 3a were confirmed by spectroscopic analyses including mass spectra (EI-MS, HR/ESIMS), 1D and 2D NMR experiments, and by the synthetic conversion into their corresponding methyl esters 1b - 3b. The algal extract and its components were comparatively examined against several pathogenic microorganisms, and brine shrimps for cytotoxicity.
AB - From the dichloromethane extract of the marine green alga Ulva fasciata Delile, collected from the Mediterranean coast of Egypt, three new fatty acids, namely, (E)-11-oxo-octadeca-12-enoic acid (1a), (E)-11-hydroxy-octadeca-12-enoic acid (2a) and 6-hydroxy-oct-7-enoic acid (3a) together with cholesterol were isolated. Analysis of the unpolar part of the extract using GC-MS detected the existence of further ten compounds, namely, dimethylsulfoxide, dimethylsulfone, phenylacetamide, 6,10,14-trimethyl-pentadecan-2-one, 8-heptadecene, dodecane, tridecane, 4-oxo-pentanoic acid, hexadecanoic acid, and the naturally new 1,1'-bicyclohexyl. Structures of the isolated compounds 1a - 3a were confirmed by spectroscopic analyses including mass spectra (EI-MS, HR/ESIMS), 1D and 2D NMR experiments, and by the synthetic conversion into their corresponding methyl esters 1b - 3b. The algal extract and its components were comparatively examined against several pathogenic microorganisms, and brine shrimps for cytotoxicity.
KW - Biological activity
KW - Cytotoxicity
KW - GC-MS
KW - Marine algae
KW - New fatty acids
KW - Ulva fasciata
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U2 - 10.1515/znb-2009-1014
DO - 10.1515/znb-2009-1014
M3 - Article
AN - SCOPUS:70350169346
SN - 0932-0776
VL - 64
SP - 1199
EP - 1207
JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
JF - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
IS - 10
ER -