Three new unsaturated fatty acids from the marine green alga ulva fasciata delile

Ghada S.E. Abou-ElWafa, Mohamed Shaaban, Khaled A. Shaaban, Mohamed E.E. El-Naggar, Hartmut Laatsch

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

From the dichloromethane extract of the marine green alga Ulva fasciata Delile, collected from the Mediterranean coast of Egypt, three new fatty acids, namely, (E)-11-oxo-octadeca-12-enoic acid (1a), (E)-11-hydroxy-octadeca-12-enoic acid (2a) and 6-hydroxy-oct-7-enoic acid (3a) together with cholesterol were isolated. Analysis of the unpolar part of the extract using GC-MS detected the existence of further ten compounds, namely, dimethylsulfoxide, dimethylsulfone, phenylacetamide, 6,10,14-trimethyl-pentadecan-2-one, 8-heptadecene, dodecane, tridecane, 4-oxo-pentanoic acid, hexadecanoic acid, and the naturally new 1,1'-bicyclohexyl. Structures of the isolated compounds 1a - 3a were confirmed by spectroscopic analyses including mass spectra (EI-MS, HR/ESIMS), 1D and 2D NMR experiments, and by the synthetic conversion into their corresponding methyl esters 1b - 3b. The algal extract and its components were comparatively examined against several pathogenic microorganisms, and brine shrimps for cytotoxicity.

Original languageEnglish
Pages (from-to)1199-1207
Number of pages9
JournalZeitschrift fur Naturforschung - Section B Journal of Chemical Sciences
Volume64
Issue number10
DOIs
StatePublished - 2009

Keywords

  • Biological activity
  • Cytotoxicity
  • GC-MS
  • Marine algae
  • New fatty acids
  • Ulva fasciata

ASJC Scopus subject areas

  • General Chemistry

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