Abstract
Thrombotic microangiopathy (TMA) is a severe disorder with poor outcomes. The cause is unknown for many patients, although TMA is associated with connective tissue disorders, including systemic lupus erythematosus (SLE). While uncommon, TMA is one of the most serious complications of SLE and in many cases may be resistant to therapy. We report a patient with SLE complicated by TMA that was refractory to standard therapy but responded well to eculizumab, with continued remission after 1 year of follow-up. Eculizumab might be useful in the management of resistant cases of TMA caused by SLE.
| Original language | English |
|---|---|
| Pages (from-to) | 127-130 |
| Number of pages | 4 |
| Journal | American Journal of Kidney Diseases |
| Volume | 65 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2015 |
Bibliographical note
Publisher Copyright:© 2014 by the National Kidney Foundation, Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
Keywords
- Acute kidney injury (AKI)
- Atypical hemolytic uremic syndrome (aHUS)
- Eculizumab
- Kidney biopsy
- Lupus nephritis
- Proteinuria
- Systemic lupus erythematosus (SLE)
- Thrombotic microangiopathy (TMA)
ASJC Scopus subject areas
- Nephrology