Thymine DNA glycosylase is a positive regulator of Wnt signaling in colorectal cancer

Xuehe Xu, Tianxin Yu, Jiandang Shi, Xi Chen, Wen Zhang, Ting Lin, Zhihong Liu, Yadong Wang, Zheng Zeng, Chi Wang, Mingsong Li, Chunming Liu

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Wnt signaling plays an important role in colorectal cancer (CRC). Although the mechanisms of β-catenin degradation have been well studied, the mechanism by which β-catenin activates transcription is still not fully understood. While screening a panel of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling.TDGinteracts with the transcription factor TCF4 and coactivator CREB-binding protein/p300 in the Wnt pathway. Knocking down TDG by shRNAs inhibited the proliferation of CRC cells in vitro and in vivo. In CRC patients, TDG levels were significantly higher in tumor tissues than in the adjacent normal tissues. These results suggest that TDG warrants consideration as a potential biomarker for CRC and as a target for CRC treatment.

Original languageEnglish
Pages (from-to)8881-8890
Number of pages10
JournalJournal of Biological Chemistry
Volume289
Issue number13
DOIs
StatePublished - Mar 30 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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