Thyroid gland volumes in premature infants using serial ultrasounds

Safdar S. Khan, Irene Hong-McAtee, Vesna Martich Kriss, Scott Stevens, Timothy Crawford, Mina Hanna, Henrietta Bada, Nirmala Desai

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: There is a gap in knowledge about the postnatal growth of thyroid gland in preterm infants. Objective: To determine postnatal growth of thyroid gland in preterm infants. Methods: Thyroid gland volume was calculated in 57 prospectively enrolled preterm infants by measuring serial longitudinal, antero-posterior, and transverse dimensions of thyroid gland with ultrasound. Data were analyzed by using the Wilcoxon and independent t test. Results: There was a significant correlation between thyroid volume (TV) and birthweight (BW) (p = 0.01), and between TV and gestational age (p = 0.02). However, unexpectedly, 12 infants had a decrease in TV between the first and second ultrasounds. Infants with late onset bacterial sepsis had lower TVs on their second ultrasounds than infants without sepsis. Conclusions: Thyroid ultrasound in preterm infants provides noninvasive and quick approach to determine TV and morphology. TV in preterm infants correlates positively with BW and gestational age. However, postnatal growth of thyroid gland is variable and may seemingly be affected by postnatal factors.

Original languageEnglish
Pages (from-to)1353-1358
Number of pages6
JournalJournal of Perinatology
Issue number10
StatePublished - Oct 1 2018

Bibliographical note

Publisher Copyright:
© 2018, Nature America, Inc., part of Springer Nature.

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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