Thyroxine-induced metamorphosis in the Axolotl (Ambystoma mexicanum)

Peggy S. Coots, Ashley W. Seifert

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The axolotl (Ambystoma mexicanum) has remained an important model for regeneration and developmental biology for over a century. Although axolotls in captive-bred colonies usually exist in an aquatic form, they retain the ability to undergo metamorphosis following exposure to thyroid hormone. Here we present a robust method for inducing metamorphosis in adult axolotls that results in high survivability and produces terrestrial animals that can be maintained in long-term captivity.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalMethods in Molecular Biology
StatePublished - 2015

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media New York 2015


  • Ambystoma
  • Axolotl
  • Metamorphosis
  • Regeneration
  • Salamander
  • T
  • Thyroid hormone
  • Thyroxine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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