TY - JOUR
T1 - Ticagrelor Reduces Thromboinflammatory Markers in Patients With Pneumonia
AU - Sexton, Travis R.
AU - Zhang, Guoying
AU - Macaulay, Tracy E.
AU - Callahan, Leigh A.
AU - Charnigo, Richard
AU - Vsevolozhskaya, Olga A.
AU - Li, Zhenyu
AU - Smyth, Susan
N1 - Publisher Copyright:
© 2018
PY - 2018/8
Y1 - 2018/8
N2 - Despite treatment advances for sepsis and pneumonia, significant improvements in outcome have not been realized. Antiplatelet therapy may improve outcome in pneumonia and sepsis. In this study, the authors show that ticagrelor reduced leukocytes with attached platelets as well as the inflammatory biomarker interleukin (IL)-6. Pneumonia patients receiving ticagrelor required less supplemental oxygen and lung function tests trended toward improvement. Disruption of the P2Y12 receptor in a murine model protected against inflammatory response, lung permeability, and mortality. Results indicate a mechanistic link between platelets, leukocytes, and lung injury in settings of pneumonia and sepsis, and suggest possible therapeutic approaches to reduce complications.(Targeting
AB - Despite treatment advances for sepsis and pneumonia, significant improvements in outcome have not been realized. Antiplatelet therapy may improve outcome in pneumonia and sepsis. In this study, the authors show that ticagrelor reduced leukocytes with attached platelets as well as the inflammatory biomarker interleukin (IL)-6. Pneumonia patients receiving ticagrelor required less supplemental oxygen and lung function tests trended toward improvement. Disruption of the P2Y12 receptor in a murine model protected against inflammatory response, lung permeability, and mortality. Results indicate a mechanistic link between platelets, leukocytes, and lung injury in settings of pneumonia and sepsis, and suggest possible therapeutic approaches to reduce complications.(Targeting
KW - inflammation
KW - leukocytes
KW - platelets
KW - pneumonia
KW - sepsis
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U2 - 10.1016/j.jacbts.2018.05.005
DO - 10.1016/j.jacbts.2018.05.005
M3 - Article
AN - SCOPUS:85053848505
SN - 2452-302X
VL - 3
SP - 435
EP - 449
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 4
ER -