Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Erick X. Pérez-Guzmán; Petraleigh Pantoja; Crisanta Serrano-Collazo; Mariah A. Hassert; Alexandra Ortiz-Rosa; Idia V. Rodríguez; Luis Giavedoni; Vida Hodara; Laura Parodi; Lorna Cruz; Teresa Arana; Laura J. White; Melween I. Martínez; Daniela Weiskopf; James D. Brien; Aravinda de Silva; Amelia K. Pinto; Carlos A. Sariol

doi:10.1038/s41467-019-12295-2

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Erick X. Pérez-Guzmán, Petraleigh Pantoja, Crisanta Serrano-Collazo, Mariah A. Hassert, Alexandra Ortiz-Rosa, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Laura J. White, Melween I. Martínez, Daniela Weiskopf, James D. Brien, Aravinda de Silva, Amelia K. Pinto, Carlos A. Sariol

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Abstract

Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

Original language	English
Article number	4316
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-12295-2
State	Published - Dec 1 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/s41467-019-12295-2

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Pérez-Guzmán, E. X., Pantoja, P., Serrano-Collazo, C., Hassert, M. A., Ortiz-Rosa, A., Rodríguez, I. V., Giavedoni, L., Hodara, V., Parodi, L., Cruz, L., Arana, T., White, L. J., Martínez, M. I., Weiskopf, D., Brien, J. D., de Silva, A., Pinto, A. K., & Sariol, C. A. (2019). Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Nature Communications, 10(1), Article 4316. https://doi.org/10.1038/s41467-019-12295-2

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abstract = "Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.",

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Pérez-Guzmán, EX, Pantoja, P, Serrano-Collazo, C, Hassert, MA, Ortiz-Rosa, A, Rodríguez, IV, Giavedoni, L, Hodara, V, Parodi, L, Cruz, L, Arana, T, White, LJ, Martínez, MI, Weiskopf, D, Brien, JD, de Silva, A, Pinto, AK & Sariol, CA 2019, 'Time elapsed between Zika and dengue virus infections affects antibody and T cell responses', Nature Communications, vol. 10, no. 1, 4316. https://doi.org/10.1038/s41467-019-12295-2

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AU - Pérez-Guzmán, Erick X.

AU - Pantoja, Petraleigh

AU - Serrano-Collazo, Crisanta

AU - Hassert, Mariah A.

AU - Ortiz-Rosa, Alexandra

AU - Rodríguez, Idia V.

AU - Giavedoni, Luis

AU - Hodara, Vida

AU - Parodi, Laura

AU - Cruz, Lorna

AU - Arana, Teresa

AU - White, Laura J.

AU - Martínez, Melween I.

AU - Weiskopf, Daniela

AU - Brien, James D.

AU - de Silva, Aravinda

AU - Pinto, Amelia K.

AU - Sariol, Carlos A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

AB - Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

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Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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