Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Erick X. Pérez-Guzmán; Petraleigh Pantoja; Crisanta Serrano-Collazo; Mariah A. Hassert; Alexandra Ortiz-Rosa; Idia V. Rodríguez; Luis Giavedoni; Vida Hodara; Laura Parodi; Lorna Cruz; Teresa Arana; Laura J. White; Melween I. Martínez; Daniela Weiskopf; James D. Brien; Aravinda de Silva; Amelia K. Pinto; Carlos A. Sariol

doi:10.1038/s41467-019-12295-2

Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Erick X. Pérez-Guzmán, Petraleigh Pantoja, Crisanta Serrano-Collazo, Mariah A. Hassert, Alexandra Ortiz-Rosa, Idia V. Rodríguez, Luis Giavedoni, Vida Hodara, Laura Parodi, Lorna Cruz, Teresa Arana, Laura J. White, Melween I. Martínez, Daniela Weiskopf, James D. Brien, Aravinda de Silva, Amelia K. Pinto, Carlos A. Sariol

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

Original language	English
Article number	4316
Journal	Nature Communications
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41467-019-12295-2
State	Published - Dec 1 2019

Bibliographical note

Publisher Copyright:
© 2019, The Author(s).

Funding

We thank all the staff of the Caribbean Primate Research Center and Animal Resources Center for their continuous support with the sample collection, schedule, and monitoring of the animals. Authors recognize the support provided by Dr. Elmer Rodriguez reviewing the statistics. This work was supported by the following grants: 2 P40 OD012217 and 2U42OD021458-15 to C.A.S. and M.I.M., K22AI104794 to J.D.B., P51OD011133 (L.G.), HHSN272201400045C to D.W., and R25GM061838 to E.X.P.-G.

Funders	Funder number
NIH Office of the Director	P40OD012217
NIH Office of the Director
National Institute of General Medical Sciences	R25GM061838
National Institute of General Medical Sciences
Division of Intramural Research, National Institute of Allergy and Infectious Diseases	K22AI104794, HHSN272201400045C
Division of Intramural Research, National Institute of Allergy and Infectious Diseases

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-019-12295-2

Cite this

Pérez-Guzmán, E. X., Pantoja, P., Serrano-Collazo, C., Hassert, M. A., Ortiz-Rosa, A., Rodríguez, I. V., Giavedoni, L., Hodara, V., Parodi, L., Cruz, L., Arana, T., White, L. J., Martínez, M. I., Weiskopf, D., Brien, J. D., de Silva, A., Pinto, A. K., & Sariol, C. A. (2019). Time elapsed between Zika and dengue virus infections affects antibody and T cell responses. Nature Communications, 10(1), Article 4316. https://doi.org/10.1038/s41467-019-12295-2

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abstract = "Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.",

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Pérez-Guzmán, EX, Pantoja, P, Serrano-Collazo, C, Hassert, MA, Ortiz-Rosa, A, Rodríguez, IV, Giavedoni, L, Hodara, V, Parodi, L, Cruz, L, Arana, T, White, LJ, Martínez, MI, Weiskopf, D, Brien, JD, de Silva, A, Pinto, AK & Sariol, CA 2019, 'Time elapsed between Zika and dengue virus infections affects antibody and T cell responses', Nature Communications, vol. 10, no. 1, 4316. https://doi.org/10.1038/s41467-019-12295-2

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AU - Pérez-Guzmán, Erick X.

AU - Pantoja, Petraleigh

AU - Serrano-Collazo, Crisanta

AU - Hassert, Mariah A.

AU - Ortiz-Rosa, Alexandra

AU - Rodríguez, Idia V.

AU - Giavedoni, Luis

AU - Hodara, Vida

AU - Parodi, Laura

AU - Cruz, Lorna

AU - Arana, Teresa

AU - White, Laura J.

AU - Martínez, Melween I.

AU - Weiskopf, Daniela

AU - Brien, James D.

AU - de Silva, Aravinda

AU - Pinto, Amelia K.

AU - Sariol, Carlos A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

AB - Zika virus (ZIKV) and dengue virus (DENV) are co-endemic in many parts of the world, but the impact of ZIKV infection on subsequent DENV infection is not well understood. Here we show in rhesus macaques that the time elapsed after ZIKV infection affects the immune response to DENV infection. We show that previous ZIKV exposure increases the magnitude of the antibody and T cell responses against DENV. The time interval between ZIKV and subsequent DENV infection further affects the immune response. A mid-convalescent period of 10 months after ZIKV infection results in higher and more durable antibody and T cell responses to DENV infection than a short period of 2 months. In contrast, previous ZIKV infection does not affect DENV viremia or pro-inflammatory status. Collectively, we find no evidence of a detrimental effect of ZIKV immunity in a subsequent DENV infection. This supports the implementation of ZIKV vaccines that could also boost immunity against future DENV epidemics.

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Time elapsed between Zika and dengue virus infections affects antibody and T cell responses

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

UN SDGs

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