Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

doi:10.1038/s41372-020-0594-4

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Pediatrics

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36 Scopus citations

Abstract

Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

Original language	English
Pages (from-to)	616-627
Number of pages	12
Journal	Journal of Perinatology
Volume	40
Issue number	4
DOIs	https://doi.org/10.1038/s41372-020-0594-4
State	Published - Apr 1 2020

Bibliographical note

Publisher Copyright:
© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-020-0594-4

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@article{720c0a25d2524e84b47167e9ce4c2744,

title = "Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes",

abstract = "Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks{\textquoteright} postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.",

author = "Harmon, {Heidi M.} and Jensen, {Erik A.} and Sylvia Tan and Chaudhary, {Aasma S.} and Slaughter, {Jonathan L.} and Bell, {Edward F.} and Wyckoff, {Myra H.} and Hensman, {Angelita M.} and Sokol, {Gregory M.} and DeMauro, {Sara B.} and Caplan, {Michael S.} and Laptook, {Abbott R.} and Martin Keszler and Vohr, {Betty R.} and Barbara Alksninis and Basso, {Kristin M.} and Robert Burke and Melinda Caskey and Katharine Johnson and Keszler, {Mary Lenore} and Knoll, {Andrea M.} and Leach, {Theresa M.} and Emilee Little and McGowan, {Elisabeth C.} and Elisa Vieira and Watson, {Victoria E.} and Suzy Ventura and Walsh, {Michele C.} and Hibbs, {Anna Maria} and Wilson-Costello, {Deanne E.} and Newman, {Nancy S.} and Payne, {Allison H.} and Siner, {Bonnie S.} and Monika Bhola and Gulgun Yalcinkaya and Truog, {William E.} and Pallotto, {Eugenia K.} and Kilbride, {Howard W.} and Cheri Gauldin and Anne Holmes and Kathy Johnson and Allison Scott and Kurt Schibler and Donovan, {Edward F.} and Cathy Grisby and Kate Bridges and Barbara Alexander and Fischer, {Estelle E.} and Mincey, {Holly L.} and Goldstein, {Ricki F.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2020",

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doi = "10.1038/s41372-020-0594-4",

language = "English",

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pages = "616--627",

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TY - JOUR

T1 - Timing of postnatal steroids for bronchopulmonary dysplasia

T2 - association with pulmonary and neurodevelopmental outcomes

AU - Harmon, Heidi M.

AU - Jensen, Erik A.

AU - Tan, Sylvia

AU - Chaudhary, Aasma S.

AU - Slaughter, Jonathan L.

AU - Bell, Edward F.

AU - Wyckoff, Myra H.

AU - Hensman, Angelita M.

AU - Sokol, Gregory M.

AU - DeMauro, Sara B.

AU - Caplan, Michael S.

AU - Laptook, Abbott R.

AU - Keszler, Martin

AU - Vohr, Betty R.

AU - Alksninis, Barbara

AU - Basso, Kristin M.

AU - Burke, Robert

AU - Caskey, Melinda

AU - Johnson, Katharine

AU - Keszler, Mary Lenore

AU - Knoll, Andrea M.

AU - Leach, Theresa M.

AU - Little, Emilee

AU - McGowan, Elisabeth C.

AU - Vieira, Elisa

AU - Watson, Victoria E.

AU - Ventura, Suzy

AU - Walsh, Michele C.

AU - Hibbs, Anna Maria

AU - Wilson-Costello, Deanne E.

AU - Newman, Nancy S.

AU - Payne, Allison H.

AU - Siner, Bonnie S.

AU - Bhola, Monika

AU - Yalcinkaya, Gulgun

AU - Truog, William E.

AU - Pallotto, Eugenia K.

AU - Kilbride, Howard W.

AU - Gauldin, Cheri

AU - Holmes, Anne

AU - Johnson, Kathy

AU - Scott, Allison

AU - Schibler, Kurt

AU - Donovan, Edward F.

AU - Grisby, Cathy

AU - Bridges, Kate

AU - Alexander, Barbara

AU - Fischer, Estelle E.

AU - Mincey, Holly L.

AU - Goldstein, Ricki F.

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

AB - Objective: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). Study design: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks’ postmenstrual age was used to produce adjusted odds ratios (aOR). Results: Compared with infants in the reference group (22–28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50–63 (aOR 1.77, 95% CI 1.03–3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44–6.48). The aOR for NDI did not vary significantly by age of PNS exposure. Conclusion: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.

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JF - Journal of Perinatology

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ER -

Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes

Abstract

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