Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

Paul H. Sato; Edward D. Hall

doi:10.1111/j.1471-4159.1992.tb10972.x

Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

Paul H. Sato, Edward D. Hall

Neuroscience

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, α‐tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury‐induced depletion of ascorbic acid may occur without irreversible tissue damage.

Original language	English
Pages (from-to)	2263-2268
Number of pages	6
Journal	Journal of Neurochemistry
Volume	58
Issue number	6
DOIs	https://doi.org/10.1111/j.1471-4159.1992.tb10972.x
State	Published - Jun 1992

Keywords

Ascorbic acid
Brain injury protection
Ischemia‐reperfusion injury
Lipid peroxidation inhibitor
Tirilazad mesylate
α‐Tocopherol

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

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10.1111/j.1471-4159.1992.tb10972.x

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title = "Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury",

abstract = "Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, α‐tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury‐induced depletion of ascorbic acid may occur without irreversible tissue damage.",

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T1 - Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

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AU - Hall, Edward D.

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N2 - Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, α‐tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury‐induced depletion of ascorbic acid may occur without irreversible tissue damage.

AB - Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, α‐tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury‐induced depletion of ascorbic acid may occur without irreversible tissue damage.

KW - Ascorbic acid

KW - Brain injury protection

KW - Ischemia‐reperfusion injury

KW - Lipid peroxidation inhibitor

KW - Tirilazad mesylate

KW - α‐Tocopherol

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Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

Abstract

Keywords

ASJC Scopus subject areas

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