Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury

Paul H. Sato, Edward D. Hall

Research output: Contribution to journalArticlepeer-review

69 Scopus citations


Abstract: Brain concentrations of the antioxidant vitamins C and E decreased following unilateral carotid occlusion and reperfusion for 2 or 24 h in gerbils. Administration of the 21‐aminosteroid inhibitor of lipid peroxidation, tirilazad mesylate (U74006F), prevented the decrease in level of both of these vitamins following 2 h of reperfusion. After 24 h of reperfusion, however, α‐tocopherol (vitamin E) continued to be protected, but ascorbic acid (vitamin C) showed a pronounced decrease in content. The changes in concentrations of these vitamins are consistent with U74006F acting to inhibit peroxidation in the CNS by scavenging of lipid peroxyl radicals and suggest that, in the presence of this agent, injury‐induced depletion of ascorbic acid may occur without irreversible tissue damage.

Original languageEnglish
Pages (from-to)2263-2268
Number of pages6
JournalJournal of Neurochemistry
Issue number6
StatePublished - Jun 1992


  • Ascorbic acid
  • Brain injury protection
  • Ischemia‐reperfusion injury
  • Lipid peroxidation inhibitor
  • Tirilazad mesylate
  • α‐Tocopherol

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Tirilazad Mesylate Protects Vitamins C and E in Brain Ischemia‐Reperfusion Injury'. Together they form a unique fingerprint.

Cite this