Tissue architecture and function: Dynamic reciprocity via extra- and intra-cellular matrices

Ren Xu; Aaron Boudreau; Mina J. Bissell

doi:10.1007/s10555-008-9178-z

Tissue architecture and function: Dynamic reciprocity via extra- and intra-cellular matrices

Ren Xu, Aaron Boudreau, Mina J. Bissell

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Review article › peer-review

258 Scopus citations

Abstract

Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra-to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

Original language	English
Pages (from-to)	167-176
Number of pages	10
Journal	Cancer and Metastasis Reviews
Volume	28
Issue number	1-2
DOIs	https://doi.org/10.1007/s10555-008-9178-z
State	Published - 2009

Bibliographical note

Funding Information:
Acknowledgements We apologize to those whose work could not be cited due to space limitations. This work was supported by the Office of Biological and Environmental Research of the Department of Energy (DOE-AC03-76SF00098), the National Institutes of Health (CA112970-01), (R01CA057621) to Zena Werb and M.J.B., (R01CA064786) to M.J.B. and the Breast Cancer Research Program (BCRP) of the Department of Defense (DOD) (Innovator Award) to M.J.B. M.JB. is a Distinguished Scientist of the OBER Office of the DOE. Support was also provided by a DOD BCRP postdoctoral fellowship DAMD17-02-1-0441 to R.X., a predoctoral fellowship W81XWH-05-1-0339 to A.T.B, and by a California BCRP Dissertation Award to ATB.

Keywords

Acinar morphogenesis
Chromatin organization
Cytoskeleton
Extracellular matrix
Mammary-specific function
Microenvironment
Tissue architecture

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10555-008-9178-z

Cite this

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title = "Tissue architecture and function: Dynamic reciprocity via extra- and intra-cellular matrices",

abstract = "Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra-to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.",

keywords = "Acinar morphogenesis, Chromatin organization, Cytoskeleton, Extracellular matrix, Mammary-specific function, Microenvironment, Tissue architecture",

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note = "Funding Information: Acknowledgements We apologize to those whose work could not be cited due to space limitations. This work was supported by the Office of Biological and Environmental Research of the Department of Energy (DOE-AC03-76SF00098), the National Institutes of Health (CA112970-01), (R01CA057621) to Zena Werb and M.J.B., (R01CA064786) to M.J.B. and the Breast Cancer Research Program (BCRP) of the Department of Defense (DOD) (Innovator Award) to M.J.B. M.JB. is a Distinguished Scientist of the OBER Office of the DOE. Support was also provided by a DOD BCRP postdoctoral fellowship DAMD17-02-1-0441 to R.X., a predoctoral fellowship W81XWH-05-1-0339 to A.T.B, and by a California BCRP Dissertation Award to ATB.",

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language = "English",

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AU - Xu, Ren

AU - Boudreau, Aaron

AU - Bissell, Mina J.

N1 - Funding Information: Acknowledgements We apologize to those whose work could not be cited due to space limitations. This work was supported by the Office of Biological and Environmental Research of the Department of Energy (DOE-AC03-76SF00098), the National Institutes of Health (CA112970-01), (R01CA057621) to Zena Werb and M.J.B., (R01CA064786) to M.J.B. and the Breast Cancer Research Program (BCRP) of the Department of Defense (DOD) (Innovator Award) to M.J.B. M.JB. is a Distinguished Scientist of the OBER Office of the DOE. Support was also provided by a DOD BCRP postdoctoral fellowship DAMD17-02-1-0441 to R.X., a predoctoral fellowship W81XWH-05-1-0339 to A.T.B, and by a California BCRP Dissertation Award to ATB.

PY - 2009

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N2 - Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra-to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

AB - Mammary gland development, functional differentiation, and homeostasis are orchestrated and sustained by a balance of biochemical and biophysical cues from the organ's microenvironment. The three-dimensional microenvironment of the mammary gland, predominantly 'encoded' by a collaboration between the extracellular matrix (ECM), hormones, and growth factors, sends signals from ECM receptors through the cytoskeletal intracellular matrix to nuclear and chromatin structures resulting in gene expression; the ECM in turn is regulated and remodeled by signals from the nucleus. In this chapter, we discuss how coordinated ECM deposition and remodeling is necessary for mammary gland development, how the ECM provides structural and biochemical cues necessary for tissue-specific function, and the role of the cytoskeleton in mediating the extra-to intracellular dialogue occurring between the nucleus and the microenvironment. When operating normally, the cytoskeletal-mediated dynamic and reciprocal integration of tissue architecture and function directs mammary gland development, tissue polarity, and ultimately, tissue-specific gene expression. Cancer occurs when these dynamic interactions go awry for an extended time.

KW - Acinar morphogenesis

KW - Chromatin organization

KW - Cytoskeleton

KW - Extracellular matrix

KW - Mammary-specific function

KW - Microenvironment

KW - Tissue architecture

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JO - Cancer and Metastasis Reviews

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IS - 1-2

ER -

Tissue architecture and function: Dynamic reciprocity via extra- and intra-cellular matrices

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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