Tissue doppler imaging of right ventricular decompensation in pulmonary hypertension

Marc A. Simon, Navin Rajagopalan, Michael A. Mathier, Sanjeev G. Shroff, Michael R. Pinsky, Angel López-Candales

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Right ventricular (RV) function is closely linked to outcomes in pulmonary hypertension (PH). The authors sought to evaluate RV myocardial strain in 3 groups of patients: normal, PH with compensated RV function (PH-C), and PH with decompensated RV function (PH-D). Fifty-six patients (aged 56±12 years; 40 women; mean pulmonary artery pressure [MPAP] range, 13-82 mm Hg) underwent right heart catheterization and 2-dimensional echocardiography with tissue Doppler imaging of the RV. Right atrial pressures were 6±3, 5±2, and 14±4 mm Hg; MPAP values were 19±3, 44±15, and 56±13 mm Hg; pulmonary vascular resistances were 1.4±0.4, 7.9±5.1, and 11.5±6.6 Wood units; and cardiac indices were 3.4±0.9, 2.8±0.8, and 2.2±0.7 L/min/m2 (P<.05 for all for normal, PH-C, and PH-D patients), respectively. RV free wall strain decreased significantly among all 3 groups (-26%±6%, -19%±7%, and -14%±5%; P<.0001). RV free wall strain decreases in PH without hemodynamically decompensated RV function suggesting it may be a preceding step in the development of RV failure. This may be of particular use in following patients sequentially.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalCongestive Heart Failure
Issue number6
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine


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