Tissue plasminogen activator associated pulmonary hemorrhage in patient with ACTA2-associated arteriopathy

Travis G. Hughes, Mark A. Wurth, Mary B. Sheppard

Research output: Contribution to journalArticlepeer-review

Abstract

Pulmonary hemorrhage after administration of tissue plasminogen activator (tPA) is a rare complication. We present a 15-year-old boy with a heterozygous pathogenic variant in ACTA2 who presented with right brachial artery aneurysm thrombosis treated initially with tPA, resulting in pulmonary hemorrhage. We hypothesize that the underlying pulmonary abnormalities caused by the pathogenic ACTA2 variant may be a risk factor for pulmonary hemorrhage after tPA administration.

Original languageEnglish
Article number101558
JournalJournal of Vascular Surgery Cases, Innovations and Techniques
Volume10
Issue number6
DOIs
StatePublished - Dec 2024

Bibliographical note

Publisher Copyright:
© 2024 The Author(s)

Keywords

  • ACTA2
  • Brachial artery aneurysm
  • Pulmonary hemorrhage
  • Thrombosis

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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