TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Y. Wu; B. P. Zhou

doi:10.1038/sj.bjc.6605530

TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Y. Wu, B. P. Zhou

Research output: Contribution to journal › Short survey › peer-review

635 Scopus citations

Abstract

Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

Original language	English
Pages (from-to)	639-644
Number of pages	6
Journal	British Journal of Cancer
Volume	102
Issue number	4
DOIs	https://doi.org/10.1038/sj.bjc.6605530
State	Published - Feb 2010

Bibliographical note

Funding Information:
We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

Keywords

EMT
NF-κB
Snail
TNF-α

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjc.6605530

Cite this

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title = "TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion",

abstract = "Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.",

keywords = "EMT, NF-κB, Snail, TNF-α",

author = "Y. Wu and Zhou, {B. P.}",

note = "Funding Information: We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).",

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doi = "10.1038/sj.bjc.6605530",

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AU - Wu, Y.

AU - Zhou, B. P.

N1 - Funding Information: We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

PY - 2010/2

Y1 - 2010/2

N2 - Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

AB - Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

KW - EMT

KW - NF-κB

KW - Snail

KW - TNF-α

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U2 - 10.1038/sj.bjc.6605530

DO - 10.1038/sj.bjc.6605530

M3 - Short survey

C2 - 20087353

AN - SCOPUS:76949084622

SN - 0007-0920

VL - 102

SP - 639

EP - 644

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 4

ER -

TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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