TNF-α/NFκ-B/Snail pathway in cancer cell migration and invasion

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580 Scopus citations

Abstract

Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-B pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.

Original languageEnglish
Pages (from-to)639-644
Number of pages6
JournalBritish Journal of Cancer
Volume102
Issue number4
DOIs
StatePublished - Feb 2010

Bibliographical note

Funding Information:
We apologize to the many contributors of this field whose work is important but that we were unable to cite here. Our study is supported by grants from NIH (RO1CA125454), the Susan G Komen Foundation (KG081310) and the Mary Kay Ash Foundation(to BP Zhou).

Keywords

  • EMT
  • NF-κB
  • Snail
  • TNF-α

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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