Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account.
|Number of pages||5|
|Journal||Clinical Pharmacology and Therapeutics|
|State||Published - Oct 1979|
ASJC Scopus subject areas
- Pharmacology (medical)