Tobramycin pharmacokinetics in morbidly obese patients

Robert A. Blouin, Henry J. Mann, Ward O. Griffen, Larry A. Bauer, Kenneth E. Record

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account.

Original languageEnglish
Pages (from-to)508-512
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume26
Issue number4
DOIs
StatePublished - Oct 1979

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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