Tobramycin pharmacokinetics in morbidly obese patients

Robert A. Blouin; Henry J. Mann; Ward O. Griffen; Larry A. Bauer; Kenneth E. Record

doi:10.1002/cpt1979264508

Tobramycin pharmacokinetics in morbidly obese patients

Robert A. Blouin, Henry J. Mann, Ward O. Griffen, Larry A. Bauer, Kenneth E. Record

Pharmacy Practice and Science

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Abstract

Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (V_area was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize V_area to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account.

Original language	English
Pages (from-to)	508-512
Number of pages	5
Journal	Clinical Pharmacology and Therapeutics
Volume	26
Issue number	4
DOIs	https://doi.org/10.1002/cpt1979264508
State	Published - Oct 1979

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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AU - Blouin, Robert A.

AU - Mann, Henry J.

AU - Griffen, Ward O.

AU - Bauer, Larry A.

AU - Record, Kenneth E.

PY - 1979/10

Y1 - 1979/10

N2 - Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account.

AB - Tobramycin kinetics were examined in 9 morbidly obese women following a single intavenous (120 mg) bolus. After the injection, serum elimination conformed to a 2-compartment open model with a and β t 1 2s of 0.285 and 2.1 hr. The volume of distribution (Varea was determined to be 0.44 1/kg ideal body weight (IBW) and 0.20 1/kg total body weight (TBW). To normalize Varea to 0.26 1/kg, 58% of the patients' adipose weight (TBW - IBW) must also be taken into account.

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Tobramycin pharmacokinetics in morbidly obese patients

Abstract

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