Tombusvirus-Host Interactions: Co-Opted Evolutionarily Conserved Host Factors Take Center Court

Research output: Contribution to journalReview articlepeer-review

78 Scopus citations


Plant positive-strand (+)RNA viruses are intracellular infectious agents that reorganize subcellular membranes and rewire the cellular metabolism of host cells to achieve viral replication in elaborate replication compartments. This review describes the viral replication process based on tombusviruses, highlighting common strategies with other plant and animal viruses. Overall, the works on Tomato bushy stunt virus (TBSV) have revealed intriguing and complex functions of co-opted cellular translation factors, heat shock proteins, DEAD-box helicases, lipid transfer proteins, and membrane-deforming proteins in virus replication. The emerging picture is that many of the co-opted host factors are from highly expressed and conserved protein families. By hijacking host proteins, phospholipids, sterols, and the actin network, TBSV exerts supremacy over the host cell to support viral replication in large replication compartments. Altogether, these advances in our understanding of tombusvirus-host interactions are broadly applicable to many other viruses, which also usurp conserved host factors for various viral processes.

Original languageEnglish
Pages (from-to)491-515
Number of pages25
JournalAnnual Review of Virology
StatePublished - Sep 29 2016


  • Co-opted cellular factors
  • Proviral host factors
  • Viral replicase complex
  • Viral replication organelle
  • Virus replication
  • Virus-host interaction

ASJC Scopus subject areas

  • Virology


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