Abstract
Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.
| Original language | English |
|---|---|
| Pages (from-to) | 189-193 |
| Number of pages | 5 |
| Journal | Physiology and Behavior |
| Volume | 96 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 8 2009 |
Bibliographical note
Funding Information:This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (# 014032) and J.M. Littleton (# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.
Keywords
- Alcohol
- C57BL/6J
- Drinking
- Mice
- Restraint
- Stress
- Topiramate
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience
