Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.
|Number of pages||5|
|Journal||Physiology and Behavior|
|State||Published - Jan 8 2009|
Bibliographical noteFunding Information:
This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (# 014032) and J.M. Littleton (# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.
ASJC Scopus subject areas
- Experimental and Cognitive Psychology
- Behavioral Neuroscience