Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice

Justin M. Farook; Ben Lewis; John M. Littleton; Susan Barron

doi:10.1016/j.physbeh.2008.08.011

Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice

Justin M. Farook
, Ben Lewis
, John M. Littleton
, Susan Barron

Psychology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.

Original language	English
Pages (from-to)	189-193
Number of pages	5
Journal	Physiology and Behavior
Volume	96
Issue number	1
DOIs	https://doi.org/10.1016/j.physbeh.2008.08.011
State	Published - Jan 8 2009

Bibliographical note

Funding Information:
This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (# 014032) and J.M. Littleton (# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.

Funding

This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (# 014032) and J.M. Littleton (# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.

Funders	Funder number
Center for Drug and Alcohol Research
National Institute on Alcohol Abuse and Alcoholism	014032, 12600
University of Kentucky

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcohol
C57BL/6J
Drinking
Mice
Restraint
Stress
Topiramate

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Access to Document

10.1016/j.physbeh.2008.08.011

Cite this

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title = "Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice",

abstract = "Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.",

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note = "Funding Information: This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (\# 014032) and J.M. Littleton (\# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.",

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AU - Lewis, Ben

AU - Littleton, John M.

AU - Barron, Susan

N1 - Funding Information: This work was supported in part by a petite research grant awarded to J.M. Farook from the Center on Drug and Alcohol Research, University of Kentucky, NIAAA Grants to S. Barron (# 014032) and J.M. Littleton (# 12600). We thank Adam Farnsworth, Amber Estes and Megan Carter for their excellent technical support towards this manuscript.

PY - 2009/1/8

Y1 - 2009/1/8

N2 - Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.

AB - Stress increases the risk for alcohol abuse and relapse behaviors. However, there are hardly any medications to counteract stress-induced alcoholism and relapse behaviors. The present study examined the effects of topiramate (intraperitoneal injections of 10, 20, and 30mg/kg) in its ability to attenuate alcohol consumption on exposure to restraint stress in C57BL/6J mice on a 2-choice test procedure. Mice were either restrained for 1h/day for 5 successive days or left unrestrained. Subsequently, the effects of topiramate were studied in post-restraint days. Results showed that restrained animals increased alcohol consumption and alcohol preference significantly compared to control group on day 5. On post-restraint days, topiramate reduced alcohol consumption and alcohol preference on days 2-5 compared to saline. This experiment suggests that one mechanism of topiramate in reducing alcohol consumption and alcohol preference may involve an interaction with stress.

KW - Alcohol

KW - C57BL/6J

KW - Drinking

KW - Mice

KW - Restraint

KW - Stress

KW - Topiramate

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Topiramate attenuates the stress-induced increase in alcohol consumption and preference in male C57BL/6J mice

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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