Total synthesis of psoralidin, an anticancer natural product

Pallab Pahari; Jürgen Rohr

doi:10.1021/jo8025884

Total synthesis of psoralidin, an anticancer natural product

Pallab Pahari, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

Original language	English
Pages (from-to)	2750-2754
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	74
Issue number	7
DOIs	https://doi.org/10.1021/jo8025884
State	Published - Apr 3 2009

ASJC Scopus subject areas

Organic Chemistry

Access to Document

10.1021/jo8025884

Cite this

@article{47ca2eb937be43329a1818b3aabc286d,

title = "Total synthesis of psoralidin, an anticancer natural product",

abstract = "A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.",

author = "Pallab Pahari and J{\"u}rgen Rohr",

year = "2009",

month = apr,

day = "3",

doi = "10.1021/jo8025884",

language = "English",

volume = "74",

pages = "2750--2754",

number = "7",

}

TY - JOUR

T1 - Total synthesis of psoralidin, an anticancer natural product

AU - Pahari, Pallab

AU - Rohr, Jürgen

PY - 2009/4/3

Y1 - 2009/4/3

N2 - A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

AB - A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

UR - http://www.scopus.com/inward/record.url?scp=64249148289&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64249148289&partnerID=8YFLogxK

U2 - 10.1021/jo8025884

DO - 10.1021/jo8025884

M3 - Article

C2 - 19254011

AN - SCOPUS:64249148289

SN - 0022-3263

VL - 74

SP - 2750

EP - 2754

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

ER -

Total synthesis of psoralidin, an anticancer natural product

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this