Total synthesis of psoralidin, an anticancer natural product

Pallab Pahari; Jürgen Rohr

doi:10.1021/jo8025884

Total synthesis of psoralidin, an anticancer natural product

Pallab Pahari, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

Original language	English
Pages (from-to)	2750-2754
Number of pages	5
Journal	Journal of Organic Chemistry
Volume	74
Issue number	7
DOIs	https://doi.org/10.1021/jo8025884
State	Published - Apr 3 2009

Funding

Funders	Funder number
National Center for Complementary and Integrative Health	R01AT002890

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo8025884

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title = "Total synthesis of psoralidin, an anticancer natural product",

abstract = "A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.",

author = "Pallab Pahari and J{\"u}rgen Rohr",

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AU - Rohr, Jürgen

PY - 2009/4/3

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AB - A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

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U2 - 10.1021/jo8025884

DO - 10.1021/jo8025884

M3 - Article

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EP - 2754

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 7

ER -

Total synthesis of psoralidin, an anticancer natural product

Abstract

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ASJC Scopus subject areas

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