Toward Optimal Ru(II) Photocages: Balancing Photochemistry, Stability, and Biocompatibility through Fine Tuning of Steric, Electronic, and Physiochemical Features

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30 Scopus citations

Abstract

Ru(II) complex photocages are used in a variety of biological applications, but the thermal stability, photosubstitution quantum yield, and biological compatibility of the most commonly used Ru(II) systems remain unoptimized. Here, multiple compounds used in photocaging applications were analyzed and found to have several unsatisfactory characteristics. To address these deficiencies, three new scaffolds were designed to improve key properties through modulation of a combination of electronic, steric, and physiochemical features. One of these new systems, containing the 2,2′-biquinoline-4,4′-dicarboxylic acid (2,2′-bicinchoninic acid) ligand, fulfills several of the requirements for an optimal photocage. Another complex, containing the 2-benzothiazol-2-yl-quinoline ligand, provides a scaffold for the creation of "dual action" agents.

Original languageEnglish
Pages (from-to)1006-1013
Number of pages8
JournalInorganic Chemistry
Volume59
Issue number2
DOIs
StatePublished - Jan 21 2020

Bibliographical note

Funding Information:
We gratefully acknowledge the National Institutes of Health (Grant GM107586) for the support of this research. Crystallographic work was made possible by the National Science Foundation (NSF) MRI program, grants CHE-0319176 and CHE-1625732.

Publisher Copyright:
Copyright © 2020 American Chemical Society.

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry

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