Towards realizing nano-enabled precision delivery in plants

Gregory V. Lowry, Juan Pablo Giraldo, Nicole F. Steinmetz, Astrid Avellan, Gozde S. Demirer, Kurt D. Ristroph, Gerald J. Wang, Christine O. Hendren, Christopher A. Alabi, Adam Caparco, Washington da Silva, Ivonne González-Gamboa, Khara D. Grieger, Su Ji Jeon, Mariya V. Khodakovskaya, Hagay Kohay, Vivek Kumar, Raja Muthuramalingam, Hanna Poffenbarger, Swadeshmukul SantraRobert D. Tilton, Jason C. White

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Nanocarriers (NCs) that can precisely deliver active agents, nutrients and genetic materials into plants will make crop agriculture more resilient to climate change and sustainable. As a research field, nano-agriculture is still developing, with significant scientific and societal barriers to overcome. In this Review, we argue that lessons can be learned from mammalian nanomedicine. In particular, it may be possible to enhance efficiency and efficacy by improving our understanding of how NC properties affect their interactions with plant surfaces and biomolecules, and their ability to carry and deliver cargo to specific locations. New tools are required to rapidly assess NC–plant interactions and to explore and verify the range of viable targeting approaches in plants. Elucidating these interactions can lead to the creation of computer-generated in silico models (digital twins) to predict the impact of different NC and plant properties, biological responses, and environmental conditions on the efficiency and efficacy of nanotechnology approaches. Finally, we highlight the need for nano-agriculture researchers and social scientists to converge in order to develop sustainable, safe and socially acceptable NCs.

Original languageEnglish
JournalNature Nanotechnology
DOIs
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2024.

ASJC Scopus subject areas

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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