Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with the amounts of tachyzoite-specific SAG1 mRNA in their brains. In contrast, neither IgG, IgA, nor IgM antibody titers increased following two different doses of challenge infection in chronically infected mice. Increased antibody titers in IgG and IgA but not IgM may be a useful indicator suggesting an occurrence of cerebral tachyzoite growth in immunocompetent individuals chronically infected with Toxoplasma gondii.
|Number of pages||6|
|Journal||Microbes and Infection|
|State||Published - Dec 2010|
Bibliographical noteFunding Information:
We thank Marlice Vonck for her assistance in collecting sera from mice, Robert Yolken and Fuller Torrey for their helpful suggestions, and Sara Perkins for her assistance in preparing the manuscript. This work is supported by a grant (#06R-1030) from The Stanley Medical Research Institute, and grants from National Institutes of Health ( AI078756, AI073576 , and AI077887 ).
- Cerebral toxoplasmosis
- Toxoplasma gondii
ASJC Scopus subject areas
- Infectious Diseases