Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection

Jatinder Singh; Carmine Graniello; Yanyan Ni; Laura Payne; Qila Sa; James Hester; Brent J. Shelton; Yasuhiro Suzuki

doi:10.1016/j.micinf.2010.07.016

Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection

Jatinder Singh, Carmine Graniello, Yanyan Ni, Laura Payne, Qila Sa, James Hester, Brent J. Shelton, Yasuhiro Suzuki

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with the amounts of tachyzoite-specific SAG1 mRNA in their brains. In contrast, neither IgG, IgA, nor IgM antibody titers increased following two different doses of challenge infection in chronically infected mice. Increased antibody titers in IgG and IgA but not IgM may be a useful indicator suggesting an occurrence of cerebral tachyzoite growth in immunocompetent individuals chronically infected with Toxoplasma gondii.

Original language	English
Pages (from-to)	1252-1257
Number of pages	6
Journal	Microbes and Infection
Volume	12
Issue number	14-15
DOIs	https://doi.org/10.1016/j.micinf.2010.07.016
State	Published - Dec 2010

Bibliographical note

Funding Information:
We thank Marlice Vonck for her assistance in collecting sera from mice, Robert Yolken and Fuller Torrey for their helpful suggestions, and Sara Perkins for her assistance in preparing the manuscript. This work is supported by a grant (#06R-1030) from The Stanley Medical Research Institute, and grants from National Institutes of Health ( AI078756, AI073576 , and AI077887 ).

Funding

We thank Marlice Vonck for her assistance in collecting sera from mice, Robert Yolken and Fuller Torrey for their helpful suggestions, and Sara Perkins for her assistance in preparing the manuscript. This work is supported by a grant (#06R-1030) from The Stanley Medical Research Institute, and grants from National Institutes of Health ( AI078756, AI073576 , and AI077887 ).

Funders	Funder number
National Institutes of Health (NIH)	AI077887, AI073576
National Institute of Allergy and Infectious Diseases	R01AI078756
Stanley Medical Research Institute

Keywords

Cerebral toxoplasmosis
Epilepsy
IgA
IgG
Schizophrenia
Toxoplasma gondii

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2010.07.016

Cite this

Singh, J., Graniello, C., Ni, Y., Payne, L., Sa, Q., Hester, J., Shelton, B. J., & Suzuki, Y. (2010). Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection. Microbes and Infection, 12(14-15), 1252-1257. https://doi.org/10.1016/j.micinf.2010.07.016

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title = "Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection",

abstract = "Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with the amounts of tachyzoite-specific SAG1 mRNA in their brains. In contrast, neither IgG, IgA, nor IgM antibody titers increased following two different doses of challenge infection in chronically infected mice. Increased antibody titers in IgG and IgA but not IgM may be a useful indicator suggesting an occurrence of cerebral tachyzoite growth in immunocompetent individuals chronically infected with Toxoplasma gondii.",

keywords = "Cerebral toxoplasmosis, Epilepsy, IgA, IgG, Schizophrenia, Toxoplasma gondii",

author = "Jatinder Singh and Carmine Graniello and Yanyan Ni and Laura Payne and Qila Sa and James Hester and Shelton, {Brent J.} and Yasuhiro Suzuki",

note = "Funding Information: We thank Marlice Vonck for her assistance in collecting sera from mice, Robert Yolken and Fuller Torrey for their helpful suggestions, and Sara Perkins for her assistance in preparing the manuscript. This work is supported by a grant (#06R-1030) from The Stanley Medical Research Institute, and grants from National Institutes of Health ( AI078756, AI073576 , and AI077887 ).",

year = "2010",

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doi = "10.1016/j.micinf.2010.07.016",

language = "English",

volume = "12",

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Singh, J, Graniello, C, Ni, Y, Payne, L, Sa, Q, Hester, J, Shelton, BJ & Suzuki, Y 2010, 'Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection', Microbes and Infection, vol. 12, no. 14-15, pp. 1252-1257. https://doi.org/10.1016/j.micinf.2010.07.016

Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection. / Singh, Jatinder; Graniello, Carmine; Ni, Yanyan et al.
In: Microbes and Infection, Vol. 12, No. 14-15, 12.2010, p. 1252-1257.

Research output: Contribution to journal › Article › peer-review

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AU - Ni, Yanyan

AU - Payne, Laura

AU - Sa, Qila

AU - Hester, James

AU - Shelton, Brent J.

AU - Suzuki, Yasuhiro

N1 - Funding Information: We thank Marlice Vonck for her assistance in collecting sera from mice, Robert Yolken and Fuller Torrey for their helpful suggestions, and Sara Perkins for her assistance in preparing the manuscript. This work is supported by a grant (#06R-1030) from The Stanley Medical Research Institute, and grants from National Institutes of Health ( AI078756, AI073576 , and AI077887 ).

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AB - Toxoplasma IgG and IgA, but not IgM, antibody titers were significantly higher in immunocompetent mice with cerebral proliferation of tachyzoites during the chronic stage of infection than those treated with sulfadiazine to inhibit the parasite growth. Their IgG and IgA antibody titers correlated significantly with the amounts of tachyzoite-specific SAG1 mRNA in their brains. In contrast, neither IgG, IgA, nor IgM antibody titers increased following two different doses of challenge infection in chronically infected mice. Increased antibody titers in IgG and IgA but not IgM may be a useful indicator suggesting an occurrence of cerebral tachyzoite growth in immunocompetent individuals chronically infected with Toxoplasma gondii.

KW - Cerebral toxoplasmosis

KW - Epilepsy

KW - IgA

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KW - Schizophrenia

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Toxoplasma IgG and IgA, but not IgM, antibody titers increase in sera of immunocompetent mice in association with proliferation of tachyzoites in the brain during the chronic stage of infection

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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