Trace element imbalances in Amyotrophic Lateral Sclerosis

S. S. Khare, W. D. Ehmann, E. J. Kasarskis, W. R. Markesbery

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Concentrations of 15 elements were determined by instrumental neutron activation analysis in brain, spinal cord, blood cells, serum and nails of Amyotrophic Lateral Sclerosis (ALS) patients and appropriately matched control subjects. Several significant imbalances were detected in trace element levels in ALS samples compared to control samples. Some of these changes are probably secondary to the loss of tissue mass, especially in spinal cord. However the widespread changes observed in Hg and Se levels in ALS tissues deserve special attention. The significance of these alterations in trace element levels in relation to the pathogenesis of ALS is discussed.

Original languageEnglish
Pages (from-to)521-532
Number of pages12
Issue number3
StatePublished - 1990


  • Amyotrophic Lateral Sclerosis
  • Blood Cells
  • Brain
  • Mercury
  • Nails
  • Neutron Activation Analysis
  • Selenium
  • Serum
  • Spinal Cord
  • Trace Elements

ASJC Scopus subject areas

  • Neuroscience (all)
  • Toxicology


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